Skilton, Rachel J., Cutcliffe, Lesley T., Barlow, David, Wang, Yibing, Salim, Omar, Lambden, Paul R. and Clarke, Ian N.
Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle
PLoS ONE, 4, (11), . (doi:10.1371/journal.pone.0007723). (PMID:19542292).
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We have applied video time lapse microscopy to the study of the chlamydial developmental cycle. Linked with accurate measures of genome replication this provides a defined framework to analyse the developmental cycle and to investigate and provide new insights into the effects of antibiotic treatments. Removal of penicillin allows recovery of the normal developmental cycle by 10-20 hrs and the process occurs by budding from aberrant RBs.
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