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Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle

Record type: Article

We have applied video time lapse microscopy to the study of the chlamydial developmental cycle. Linked with accurate measures of genome replication this provides a defined framework to analyse the developmental cycle and to investigate and provide new insights into the effects of antibiotic treatments. Removal of penicillin allows recovery of the normal developmental cycle by 10-20 hrs and the process occurs by budding from aberrant RBs.

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Citation

Skilton, Rachel J., Cutcliffe, Lesley T., Barlow, David, Wang, Yibing, Salim, Omar, Lambden, Paul R. and Clarke, Ian N. (2009) Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle PLoS ONE, 4, (11), e7723. (doi:10.1371/journal.pone.0007723). (PMID:19542292).

More information

Published date: 6 November 2009

Identifiers

Local EPrints ID: 181193
URI: http://eprints.soton.ac.uk/id/eprint/181193
ISSN: 1932-6203
PURE UUID: 1e164876-7e64-44ce-ac3f-98fa8ee552ab
ORCID for Omar Salim: ORCID iD orcid.org/0000-0002-2562-4827

Catalogue record

Date deposited: 14 Apr 2011 11:31
Last modified: 18 Jul 2017 11:59

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Contributors

Author: Rachel J. Skilton
Author: Lesley T. Cutcliffe
Author: David Barlow
Author: Yibing Wang
Author: Omar Salim ORCID iD
Author: Paul R. Lambden
Author: Ian N. Clarke

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