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Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle

Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle
Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle
We have applied video time lapse microscopy to the study of the chlamydial developmental cycle. Linked with accurate measures of genome replication this provides a defined framework to analyse the developmental cycle and to investigate and provide new insights into the effects of antibiotic treatments. Removal of penicillin allows recovery of the normal developmental cycle by 10-20 hrs and the process occurs by budding from aberrant RBs.
1932-6203
e7723
Skilton, Rachel J.
b02d4f32-609c-4074-b616-ec819b018dbe
Cutcliffe, Lesley T.
88f242f4-b4f7-46d4-a1dd-c187dd60a773
Barlow, David
604bd0b9-bc34-49d8-9f29-e2637adbd922
Wang, Yibing
a4dc0303-7006-411e-9063-c26297fac847
Salim, Omar
a8a00604-9e57-4638-8c96-5b37e75fee90
Lambden, Paul R.
4fcd536e-2d9a-4366-97c6-386e6b005698
Clarke, Ian N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Skilton, Rachel J.
b02d4f32-609c-4074-b616-ec819b018dbe
Cutcliffe, Lesley T.
88f242f4-b4f7-46d4-a1dd-c187dd60a773
Barlow, David
604bd0b9-bc34-49d8-9f29-e2637adbd922
Wang, Yibing
a4dc0303-7006-411e-9063-c26297fac847
Salim, Omar
a8a00604-9e57-4638-8c96-5b37e75fee90
Lambden, Paul R.
4fcd536e-2d9a-4366-97c6-386e6b005698
Clarke, Ian N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b

Skilton, Rachel J., Cutcliffe, Lesley T., Barlow, David, Wang, Yibing, Salim, Omar, Lambden, Paul R. and Clarke, Ian N. (2009) Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle. PLoS ONE, 4 (11), e7723. (doi:10.1371/journal.pone.0007723). (PMID:19542292)

Record type: Article

Abstract

We have applied video time lapse microscopy to the study of the chlamydial developmental cycle. Linked with accurate measures of genome replication this provides a defined framework to analyse the developmental cycle and to investigate and provide new insights into the effects of antibiotic treatments. Removal of penicillin allows recovery of the normal developmental cycle by 10-20 hrs and the process occurs by budding from aberrant RBs.

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Published date: 6 November 2009

Identifiers

Local EPrints ID: 181193
URI: http://eprints.soton.ac.uk/id/eprint/181193
ISSN: 1932-6203
PURE UUID: 1e164876-7e64-44ce-ac3f-98fa8ee552ab
ORCID for Omar Salim: ORCID iD orcid.org/0000-0002-2562-4827
ORCID for Ian N. Clarke: ORCID iD orcid.org/0000-0002-4938-1620

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Date deposited: 14 Apr 2011 11:31
Last modified: 15 Mar 2024 03:07

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Contributors

Author: Rachel J. Skilton
Author: Lesley T. Cutcliffe
Author: David Barlow
Author: Yibing Wang
Author: Omar Salim ORCID iD
Author: Paul R. Lambden
Author: Ian N. Clarke ORCID iD

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