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The biochemical aftermath of anti-amyloid immunotherapy

The biochemical aftermath of anti-amyloid immunotherapy
The biochemical aftermath of anti-amyloid immunotherapy
Immunotherapy responses were characterized by extreme variability. Considering the broad range of biological variation that characterizes aging and complicates the recognition of reliable AD biomarkers, such disparities will make the interpretation of outcomes derived from epidemiologic and therapeutic investigations challenging. Although in some cases the apparent removal of amyloid plaques by AN-1792 was impressive, proportionate alterations in the clinical progression of AD were not evident. The fact that plaque elimination did not alter the trajectory of decline into dementia suggests the likelihood that these deposits alone are not the underlying cause of dementia.
1750-1326
39
Maarouf, Chera L.
36d91918-a5ba-4f1d-81ea-37e9e9cb0ef0
Daugs, Ian D.
ece81dea-95e6-4994-96fe-dc6b4ba7e1bb
Kokjohn, Tyler A.
8876fceb-c887-4fc4-8956-4f65dfb2a0d7
Kalback, Walter M.
8fc1e50c-63e1-4c1b-9eb1-3fb665d3846f
Patton, R. Lyle
0698a6b8-58a7-4679-8889-0e8250fa68b7
Luehrs, Dean C.
c6c2ae1a-aaeb-4666-9628-8cff8ba80876
Masliah, Eliezer
1274303d-f706-49aa-a2dc-2ce734855221
Nicoll, James A. R.r
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Sabbagh, Marwan N.
20e05fea-f200-4620-8c56-bb97d49dd1ea
Beach, Thomas G.
03084824-6526-4b32-be61-5d278be9451c
Castaño, Eduardo M.
6f917d56-fe1e-4927-b92a-ee66ac5c304e
Roher, Alex E.
55dcb688-2a4c-44b3-adc3-f7e4982a7659
Maarouf, Chera L.
36d91918-a5ba-4f1d-81ea-37e9e9cb0ef0
Daugs, Ian D.
ece81dea-95e6-4994-96fe-dc6b4ba7e1bb
Kokjohn, Tyler A.
8876fceb-c887-4fc4-8956-4f65dfb2a0d7
Kalback, Walter M.
8fc1e50c-63e1-4c1b-9eb1-3fb665d3846f
Patton, R. Lyle
0698a6b8-58a7-4679-8889-0e8250fa68b7
Luehrs, Dean C.
c6c2ae1a-aaeb-4666-9628-8cff8ba80876
Masliah, Eliezer
1274303d-f706-49aa-a2dc-2ce734855221
Nicoll, James A. R.r
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Sabbagh, Marwan N.
20e05fea-f200-4620-8c56-bb97d49dd1ea
Beach, Thomas G.
03084824-6526-4b32-be61-5d278be9451c
Castaño, Eduardo M.
6f917d56-fe1e-4927-b92a-ee66ac5c304e
Roher, Alex E.
55dcb688-2a4c-44b3-adc3-f7e4982a7659

Maarouf, Chera L., Daugs, Ian D., Kokjohn, Tyler A., Kalback, Walter M., Patton, R. Lyle, Luehrs, Dean C., Masliah, Eliezer, Nicoll, James A. R.r, Sabbagh, Marwan N., Beach, Thomas G., Castaño, Eduardo M. and Roher, Alex E. (2010) The biochemical aftermath of anti-amyloid immunotherapy. Molecular Neurodegeneration, 5, 39. (doi:10.1186/1750-1326-5-39). (PMID:20929585)

Record type: Article

Abstract

Immunotherapy responses were characterized by extreme variability. Considering the broad range of biological variation that characterizes aging and complicates the recognition of reliable AD biomarkers, such disparities will make the interpretation of outcomes derived from epidemiologic and therapeutic investigations challenging. Although in some cases the apparent removal of amyloid plaques by AN-1792 was impressive, proportionate alterations in the clinical progression of AD were not evident. The fact that plaque elimination did not alter the trajectory of decline into dementia suggests the likelihood that these deposits alone are not the underlying cause of dementia.

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Published date: 7 October 2010
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 181387
URI: http://eprints.soton.ac.uk/id/eprint/181387
ISSN: 1750-1326
PURE UUID: 34ff560b-0465-42c5-8435-7b3de41573ec
ORCID for James A. R.r Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

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Date deposited: 15 Apr 2011 10:41
Last modified: 29 Oct 2019 01:54

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Contributors

Author: Chera L. Maarouf
Author: Ian D. Daugs
Author: Tyler A. Kokjohn
Author: Walter M. Kalback
Author: R. Lyle Patton
Author: Dean C. Luehrs
Author: Eliezer Masliah
Author: Marwan N. Sabbagh
Author: Thomas G. Beach
Author: Eduardo M. Castaño
Author: Alex E. Roher

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