McPherson, T., Sherman, V. J., Aslam, A., Crack, L., Chan, H., Lloyd-Lavery, A., Jones, L.E., Ardern-Jones, M and Ogg, G.
Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema
British Journal of Dermatology, 163, (3), . (doi:10.1111/j.1365-2133.2010.09866.x). (PMID:20500796).
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These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.
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