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Nanotopographical control of stem cell differentiation

Nanotopographical control of stem cell differentiation
Nanotopographical control of stem cell differentiation
Stem cells have the capacity to differentiate into various lineages, and the ability to reliably direct stem cell fate determination would have tremendous potential for basic research and clinical therapy. Nanotopography provides a useful tool for guiding differentiation, as the features are more durable than surface chemistry and can be modified in size and shape to suit the desired application. In this paper, nanotopography is examined as a means to guide differentiation, and its application is described in the context of different subsets of stem cells, with a particular focus on skeletal (mesenchymal) stem cells. To address the mechanistic basis underlying the topographical effects on stem cells, the likely contributions of indirect (biochemical signal-mediated) and direct (force-mediated) mechanotransduction are discussed. Data from proteomic research is also outlined in relation to topography-mediated fate determination, as this approach provides insight into the global molecular changes at the level of the functional effectors.

2041-7314
120623-[13pp]
McNamara, Laura E.
c5efd583-f6a3-4907-b357-1ccf4dba31cb
McMurray, Rebecca J.
2e4cf997-4e4a-4daf-9d49-09b83abde8cf
Biggs, Manus J.
90caf50f-5da2-437b-a957-d9cc57bebb14
Kantawong, Fahsai
d209298e-ac00-49f0-a9b9-39d1e82d5925
Oreffo, Richard O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
McNamara, Laura E.
c5efd583-f6a3-4907-b357-1ccf4dba31cb
McMurray, Rebecca J.
2e4cf997-4e4a-4daf-9d49-09b83abde8cf
Biggs, Manus J.
90caf50f-5da2-437b-a957-d9cc57bebb14
Kantawong, Fahsai
d209298e-ac00-49f0-a9b9-39d1e82d5925
Oreffo, Richard O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc

McNamara, Laura E., McMurray, Rebecca J., Biggs, Manus J., Kantawong, Fahsai, Oreffo, Richard O. and Dalby, Matthew J. (2010) Nanotopographical control of stem cell differentiation. Journal of Tissue Engineering, 2010 (120623), 120623-[13pp]. (doi:10.4061/2010/120623). (PMID:21350640)

Record type: Article

Abstract

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably direct stem cell fate determination would have tremendous potential for basic research and clinical therapy. Nanotopography provides a useful tool for guiding differentiation, as the features are more durable than surface chemistry and can be modified in size and shape to suit the desired application. In this paper, nanotopography is examined as a means to guide differentiation, and its application is described in the context of different subsets of stem cells, with a particular focus on skeletal (mesenchymal) stem cells. To address the mechanistic basis underlying the topographical effects on stem cells, the likely contributions of indirect (biochemical signal-mediated) and direct (force-mediated) mechanotransduction are discussed. Data from proteomic research is also outlined in relation to topography-mediated fate determination, as this approach provides insight into the global molecular changes at the level of the functional effectors.

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More information

Published date: 18 August 2010

Identifiers

Local EPrints ID: 181637
URI: http://eprints.soton.ac.uk/id/eprint/181637
ISSN: 2041-7314
PURE UUID: d9102ffc-0ea7-4453-9e43-f84743c4dab9
ORCID for Richard O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 18 Apr 2011 15:13
Last modified: 15 Mar 2024 03:03

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Contributors

Author: Laura E. McNamara
Author: Rebecca J. McMurray
Author: Manus J. Biggs
Author: Fahsai Kantawong
Author: Matthew J. Dalby

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