Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins


Hails, Lauren A., Babister, Jodie C., Inglis, Stefanie, Davis, Sean A., Oreffo, Richard O. and Mann, Stephan (2010) Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins Small, 6, (18), pp. 1986-1991. (doi:10.1002/smll.201000939). (PMID:20721953).

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Description/Abstract

Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/smll.201000939
ISSNs: 1613-6810 (print)
Keywords: osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption
Subjects: Q Science > QR Microbiology
R Medicine > RB Pathology
R Medicine > RM Therapeutics. Pharmacology
ePrint ID: 181651
Date :
Date Event
September 2010Published
Date Deposited: 18 Apr 2011 14:45
Last Modified: 18 Apr 2017 02:27
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/181651

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