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Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins

Hails, Lauren A., Babister, Jodie C., Inglis, Stefanie, Davis, Sean A., Oreffo, Richard O. and Mann, Stephan (2010) Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins Small, 6, (18), pp. 1986-1991. (doi:10.1002/smll.201000939). (PMID:20721953).

Record type: Article

Abstract

Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.

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More information

Published date: September 2010
Keywords: osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption

Identifiers

Local EPrints ID: 181651
URI: http://eprints.soton.ac.uk/id/eprint/181651
ISSN: 1613-6810
PURE UUID: 12f3bf1a-f83b-4260-9a6d-6bee2a12ac98
ORCID for Richard O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 18 Apr 2011 14:45
Last modified: 18 Jul 2017 11:58

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Contributors

Author: Lauren A. Hails
Author: Jodie C. Babister
Author: Stefanie Inglis
Author: Sean A. Davis
Author: Stephan Mann

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