Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges
1213-1216
Pfeifer, Sabine
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Perez-Andres, Martin
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Ludwig, Heinz
e1ea5005-de05-4940-a14c-4f1c8f54def9
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656
15 April 2011
Pfeifer, Sabine
f3c9d927-7ee7-4233-bdb8-c8bab8e3962d
Perez-Andres, Martin
2af73e7b-7918-400b-9687-70a83a48bc31
Ludwig, Heinz
e1ea5005-de05-4940-a14c-4f1c8f54def9
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656
Pfeifer, Sabine, Perez-Andres, Martin, Ludwig, Heinz, Sahota, Surinder S. and Zojer, Niklas
(2011)
Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis.
Leukemia, 25, .
(doi:10.1038/leu.2011.70).
(PMID:21494259)
Abstract
An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges
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Published date: 15 April 2011
Organisations:
Faculty of Medicine, Cancer Sciences
Identifiers
Local EPrints ID: 181785
URI: http://eprints.soton.ac.uk/id/eprint/181785
ISSN: 0887-6924
PURE UUID: 05ebbc93-03a4-4917-a6c1-6263860765ac
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Date deposited: 19 Apr 2011 14:11
Last modified: 14 Mar 2024 02:57
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Contributors
Author:
Sabine Pfeifer
Author:
Martin Perez-Andres
Author:
Heinz Ludwig
Author:
Surinder S. Sahota
Author:
Niklas Zojer
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