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Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis

Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges

0887-6924
1213-1216
Pfeifer, Sabine
f3c9d927-7ee7-4233-bdb8-c8bab8e3962d
Perez-Andres, Martin
2af73e7b-7918-400b-9687-70a83a48bc31
Ludwig, Heinz
e1ea5005-de05-4940-a14c-4f1c8f54def9
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656
Pfeifer, Sabine
f3c9d927-7ee7-4233-bdb8-c8bab8e3962d
Perez-Andres, Martin
2af73e7b-7918-400b-9687-70a83a48bc31
Ludwig, Heinz
e1ea5005-de05-4940-a14c-4f1c8f54def9
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656

Pfeifer, Sabine, Perez-Andres, Martin, Ludwig, Heinz, Sahota, Surinder S. and Zojer, Niklas (2011) Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis. Leukemia, 25, 1213-1216. (doi:10.1038/leu.2011.70). (PMID:21494259)

Record type: Article

Abstract

An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges

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More information

Published date: 15 April 2011
Organisations: Faculty of Medicine, Cancer Sciences

Identifiers

Local EPrints ID: 181785
URI: http://eprints.soton.ac.uk/id/eprint/181785
ISSN: 0887-6924
PURE UUID: 05ebbc93-03a4-4917-a6c1-6263860765ac

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Date deposited: 19 Apr 2011 14:11
Last modified: 16 Jul 2019 23:41

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