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Role of fibrates in reducing coronary risk: a UK Consensus

Role of fibrates in reducing coronary risk: a UK Consensus
Role of fibrates in reducing coronary risk: a UK Consensus
This paper presents the consensus reached by a panel of experts on the role of fibrates in reducing coronary heart disease (CHD). The emphasis is on the application of these agents in clinical practice. Evidence that low levels of high-density lipoprotein cholesterol (HDL-C) play a major role in the development of CHD, plus the roles of lifestyle modification and statin treatment in raising HDL-C, are briefly reviewed. Current thinking on single-agent and combination therapies with fibrates is discussed with particular relevance to patients
with low baseline HDL-C -whether receiving statins or not- and those with features of the metabolic syndrome. Recommendations on the practical use of fibrates are made in the light of recently published international guidelines on
HDL-C management and the relevant evidence base.
Coronary heart disease, diabetes, fibrates, high density lipoprotein cholesterol, metabolic syndrome, statins
0300-7995
241-247
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Byrne, Christopher D. (2004) Role of fibrates in reducing coronary risk: a UK Consensus. Current Medical Research and Opinion, 20 (2), 241-247. (doi:10.1185/030079903125002892). (PMID:15006019)

Record type: Article

Abstract

This paper presents the consensus reached by a panel of experts on the role of fibrates in reducing coronary heart disease (CHD). The emphasis is on the application of these agents in clinical practice. Evidence that low levels of high-density lipoprotein cholesterol (HDL-C) play a major role in the development of CHD, plus the roles of lifestyle modification and statin treatment in raising HDL-C, are briefly reviewed. Current thinking on single-agent and combination therapies with fibrates is discussed with particular relevance to patients
with low baseline HDL-C -whether receiving statins or not- and those with features of the metabolic syndrome. Recommendations on the practical use of fibrates are made in the light of recently published international guidelines on
HDL-C management and the relevant evidence base.

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More information

Published date: 2004
Keywords: Coronary heart disease, diabetes, fibrates, high density lipoprotein cholesterol, metabolic syndrome, statins

Identifiers

Local EPrints ID: 181963
URI: http://eprints.soton.ac.uk/id/eprint/181963
ISSN: 0300-7995
PURE UUID: 8c5ab405-b4e1-4492-964b-3762459f6b7e
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 04 May 2011 13:44
Last modified: 23 Jun 2021 01:36

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