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Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 Kb segment of DNA spanning the insulin gene and associated VNTR

Record type: Article

Recent studies have demonstrated that a locus at 11p15,5 confers susceptibility to insulin dependent diabetes mellitus (IDDM). This locus has been shown to lie within a 19 kb region. We present a detailed sequence comparison of the predominant haplotypes found in this region in a population of French Caucasian IDDM patients and controls. Identification of polymorphisms both associated and unassociated with IDDM has allowed us to define further the region of association to 4.1 kb. Ten polymorphisms within this region are in strong linkage disequilibrium with each other and extend across the insulin gene locus and the variable number tandem repeat (VNTR) situated immediately 5' to the insulin gene. These represent a set of candidate disease polymorphisms one or more of which may account for the susceptibility to IDDM.

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Citation

Lucassen, Anneke M., Julier, Cecile, Beressi, Jean-Paul, Boitard, Christian, Froguel, Philippe, Lathrop, Mark and Bell, John I. (1993) Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 Kb segment of DNA spanning the insulin gene and associated VNTR Nature Genetics, 4, pp. 305-310. (doi:10.1038/ng0793-305). (PMID:8358440).

More information

Published date: 1993

Identifiers

Local EPrints ID: 182005
URI: http://eprints.soton.ac.uk/id/eprint/182005
ISSN: 1061-4036
PURE UUID: fbe6a038-52c8-4906-bafb-64e6df8c04dc

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Date deposited: 26 Apr 2011 12:52
Last modified: 18 Jul 2017 11:58

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Contributors

Author: Cecile Julier
Author: Jean-Paul Beressi
Author: Christian Boitard
Author: Philippe Froguel
Author: Mark Lathrop
Author: John I. Bell

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