Resilience as a predictor of treatment response in posttraumatic stress disorder patients treated with venlafaxine extended release or placebo

Davidson, Jonathan, Stein, Dan J., Rothbaum, Barbara O., Pedersen, Ron, Szumski, Annette and Baldwin, David S. (2012) Resilience as a predictor of treatment response in posttraumatic stress disorder patients treated with venlafaxine extended release or placebo. Journal of Psychopharmacology, 26 (6), 778-783. (doi:10.1177/0269881111413821). (PMID:21926426)

Abstract

This post-hoc analysis evaluated resilience as a predictor of treatment response in patients with posttraumatic stress disorder (PTSD). Data were pooled from two randomized, double-blind studies conducted with adult outpatients treated with flexible doses of venlafaxine extended release (ER) 37.5 to 300 mg/day or placebo. The 17-item Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS-SX(17)) was the primary outcome measure. Baseline Connor-Davidson Resilience Scale (CD-RISC) scores for the 25-, 10-, and 2-item versions were used to predict changes in PTSD symptom severity at week 12 and symptomatic remission (CAPS-SX(17) ? 20). Analyses were conducted for the overall population and separately for the individual treatment groups. In total, pretreatment resilience predicted a positive treatment response. For the overall population, all versions of the CD-RISC predicted CAPS-SX(17) change scores and remission after controlling for variables such as treatment group and baseline symptom severity. For venlafaxine ER-treated patients, all versions of the CD-RISC were predictive of remission, but only the 10-item version was predictive of CAPS-SX(17) change score. Our results suggest that higher pretreatment resilience is generally associated with a positive treatment response. Future research may be warranted to explore the relationship between response to active treatment and the spectrum of resiliency.

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Contributors

Author: David S. Baldwin

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