The cell biology of tetrapyrroles: a life and death struggle
The cell biology of tetrapyrroles: a life and death struggle
Tetrapyrroles such as chlorophyll and heme are co-factors for essential proteins involved in a wide variety of crucial cellular functions. Nearly 2% of the proteins encoded by the Arabidopsis thaliana genome are thought to bind tetrapyrroles, demonstrating their central role in plant metabolism. Although the enzymes required for tetrapyrrole biosynthesis are well characterized, there are still major questions about the regulation of the pathway, and the transport of tetrapyrroles within cells. These issues are important, as misregulation of tetrapyrrole metabolism can lead to severe photo-oxidative stress, and because tetrapyrroles have been implicated in signaling pathways coordinating interactions between plant organelles. In this review, we discuss the cell biology of tetrapyrrole metabolism and its implications for tetrapyrroles as signaling molecules.
488-498
Mochizuki, Nobuyoshi
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Tanaka, Ryouichi
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Grimm, Bernhard
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Masuda, Tatsuru
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Moulin, Michael
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Smith, Alison G.
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Tanaka, Ayumi
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Terry, Matthew J.
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September 2010
Mochizuki, Nobuyoshi
48389b2c-faba-4407-93c1-337653226a7c
Tanaka, Ryouichi
1be49435-d20a-4855-9eed-71a718143340
Grimm, Bernhard
98796b13-7c26-4dcc-a2dc-6c9dff55b0d8
Masuda, Tatsuru
c8673133-fa80-4a6f-a4ac-7a675c20540c
Moulin, Michael
40ae50cb-d31f-42de-b516-1a146f93c0b2
Smith, Alison G.
30d591f0-8608-47bf-89ee-9278c4bef53d
Tanaka, Ayumi
c6b9971b-0ea7-45df-ba8e-7cfe0e2de2d6
Terry, Matthew J.
a8c2cd6b-8d35-4053-8d77-3841c2427c3b
Mochizuki, Nobuyoshi, Tanaka, Ryouichi, Grimm, Bernhard, Masuda, Tatsuru, Moulin, Michael, Smith, Alison G., Tanaka, Ayumi and Terry, Matthew J.
(2010)
The cell biology of tetrapyrroles: a life and death struggle.
Trends in Plant Science, 15 (9), .
(doi:10.1016/j.tplants.2010.05.012).
(PMID:20598625)
Abstract
Tetrapyrroles such as chlorophyll and heme are co-factors for essential proteins involved in a wide variety of crucial cellular functions. Nearly 2% of the proteins encoded by the Arabidopsis thaliana genome are thought to bind tetrapyrroles, demonstrating their central role in plant metabolism. Although the enzymes required for tetrapyrrole biosynthesis are well characterized, there are still major questions about the regulation of the pathway, and the transport of tetrapyrroles within cells. These issues are important, as misregulation of tetrapyrrole metabolism can lead to severe photo-oxidative stress, and because tetrapyrroles have been implicated in signaling pathways coordinating interactions between plant organelles. In this review, we discuss the cell biology of tetrapyrrole metabolism and its implications for tetrapyrroles as signaling molecules.
Text
Mochizuki et al - The cell biology of tetrapyrroles - accepted version
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Published date: September 2010
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Local EPrints ID: 182677
URI: http://eprints.soton.ac.uk/id/eprint/182677
ISSN: 1360-1385
PURE UUID: 79d7124f-3a1a-4f38-94ee-c14ba9b35b3e
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Date deposited: 28 Apr 2011 09:24
Last modified: 15 Mar 2024 02:52
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Contributors
Author:
Nobuyoshi Mochizuki
Author:
Ryouichi Tanaka
Author:
Bernhard Grimm
Author:
Tatsuru Masuda
Author:
Michael Moulin
Author:
Alison G. Smith
Author:
Ayumi Tanaka
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