The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
The currently dominant neuro-cognitive model of Attention Deficit Hyperactivity Disorder (AD/HD) presents the condition as executive dysfunction (EDF) underpinned by disturbances in the fronto-dorsal striatal circuit and associated dopaminergic branches (e.g. meso-cortical). In contrast, motivationally-based accounts focus on altered reward processes and implicate fronto-ventral striatal reward circuits and those meso-limbic branches that terminate in the ventral striatum especially the nucleus accumbens. One such account, delay aversion (DEL), presents AD/HD as a motivational style—characterised by attempts to escape or avoid delay—arising from fundamental disturbances in these reward centres. While traditionally regarded as competing, EDF and DEL models have recently been presented as complimentary accounts of two psycho-patho-physiological subtypes of AD/HD with different developmental pathways, underpinned by different cortico-striatal circuits and modulated by different branches of the dopamine system. In the current paper we describe the development of this model in more detail. We elaborate on the neuro-circuitry possibly underpinning these two pathways and explore their developmental significance within a neuro-ecological framework.
attention deficit hyperactivity disorder, dopamine, executive function, delay aversion, meso-cortical, meso-limbic, adaptation, ventral striatum, dorsal striatum, pre-frontal cortex
593-604
Sonuga-Barke, Edmund J. S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
2003
Sonuga-Barke, Edmund J. S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Sonuga-Barke, Edmund J. S.
(2003)
The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics.
Neuroscience and Biobehavioural Reviews, 27 (7), .
(doi:10.1016/j.neubiorev.2003.08.005).
Abstract
The currently dominant neuro-cognitive model of Attention Deficit Hyperactivity Disorder (AD/HD) presents the condition as executive dysfunction (EDF) underpinned by disturbances in the fronto-dorsal striatal circuit and associated dopaminergic branches (e.g. meso-cortical). In contrast, motivationally-based accounts focus on altered reward processes and implicate fronto-ventral striatal reward circuits and those meso-limbic branches that terminate in the ventral striatum especially the nucleus accumbens. One such account, delay aversion (DEL), presents AD/HD as a motivational style—characterised by attempts to escape or avoid delay—arising from fundamental disturbances in these reward centres. While traditionally regarded as competing, EDF and DEL models have recently been presented as complimentary accounts of two psycho-patho-physiological subtypes of AD/HD with different developmental pathways, underpinned by different cortico-striatal circuits and modulated by different branches of the dopamine system. In the current paper we describe the development of this model in more detail. We elaborate on the neuro-circuitry possibly underpinning these two pathways and explore their developmental significance within a neuro-ecological framework.
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Published date: 2003
Additional Information:
Review
Keywords:
attention deficit hyperactivity disorder, dopamine, executive function, delay aversion, meso-cortical, meso-limbic, adaptation, ventral striatum, dorsal striatum, pre-frontal cortex
Organisations:
Clinical Neurosciences
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Local EPrints ID: 18285
URI: http://eprints.soton.ac.uk/id/eprint/18285
ISSN: 0149-7634
PURE UUID: 09729b7e-4dea-4091-a584-abb569234f57
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Date deposited: 18 Jan 2006
Last modified: 15 Mar 2024 06:04
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Author:
Edmund J. S. Sonuga-Barke
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