Body composition in childhood inflammatory bowel disease
Body composition in childhood inflammatory bowel disease
Background & aims: little is known about the impact of disease and treatment on the pattern of growth in children with Inflammatory Bowel Disease (IBD). Significant deficits in height and weight in children with Crohn’s disease have been reported but changes in fat and fat free mass are less well defined. This study aims to describe the height, weight and body composition of a cohort of children with IBD.
Methods: height, weight, skinfold thicknesses and bioelectrical impedance analysis was performed. Disease activity was assessed with clinical scoring systems.
Results: 55 children, median age 13.7 years (range 6.5–17.7) were studied. Median (25th, 75th percentile) Standard Deviation Score for BMI, Height and Weight were ? 0.3 (? 0.97, 0.65), ? 0.56 (? 1.42, 0.06), ? 0.62 (? 1.43, 0.19). In Crohn’s disease, using multiple regression analysis disease activity measured by PCDAI was significantly inversely related to fat free mass (? ? 0.2, 95% CI ?0.17, ?0.03, p 0.005).
Conclusions: children with IBD were both under and overweight. Nutritional deficits were more common in Crohn’s disease. Fat free mass was related to disease activity in children with Crohn’s disease regardless of changes in weight. Weight or BMI may mask deficits in lean tissue in the presence of normal or increased proportions of body fat.
inflammatory bowel disease, body composition, fat free mass, paediatrics
112-115
Wiskin, Anthony E.
83fd2f91-d1b5-46ae-b237-8f1b61fdec29
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Hunt, Toby M.
022cdb61-f90c-43d2-86ab-33255aaae495
Cornelius, Victoria R.
2edd148b-5385-4534-96a3-257c17d08ac4
Afzal, Nadeem A.
5148f35e-6788-4dbd-a50f-c303a4948d60
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Beattie, R. Mark
55d81c7b-08c9-4f42-b6d3-245869badb71
February 2011
Wiskin, Anthony E.
83fd2f91-d1b5-46ae-b237-8f1b61fdec29
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Hunt, Toby M.
022cdb61-f90c-43d2-86ab-33255aaae495
Cornelius, Victoria R.
2edd148b-5385-4534-96a3-257c17d08ac4
Afzal, Nadeem A.
5148f35e-6788-4dbd-a50f-c303a4948d60
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Beattie, R. Mark
55d81c7b-08c9-4f42-b6d3-245869badb71
Wiskin, Anthony E., Wootton, Stephen A., Hunt, Toby M., Cornelius, Victoria R., Afzal, Nadeem A., Jackson, Alan A. and Beattie, R. Mark
(2011)
Body composition in childhood inflammatory bowel disease.
Clinical Nutrition, 30 (1), .
(doi:10.1016/j.clnu.2010.07.014).
(PMID:20728967)
Abstract
Background & aims: little is known about the impact of disease and treatment on the pattern of growth in children with Inflammatory Bowel Disease (IBD). Significant deficits in height and weight in children with Crohn’s disease have been reported but changes in fat and fat free mass are less well defined. This study aims to describe the height, weight and body composition of a cohort of children with IBD.
Methods: height, weight, skinfold thicknesses and bioelectrical impedance analysis was performed. Disease activity was assessed with clinical scoring systems.
Results: 55 children, median age 13.7 years (range 6.5–17.7) were studied. Median (25th, 75th percentile) Standard Deviation Score for BMI, Height and Weight were ? 0.3 (? 0.97, 0.65), ? 0.56 (? 1.42, 0.06), ? 0.62 (? 1.43, 0.19). In Crohn’s disease, using multiple regression analysis disease activity measured by PCDAI was significantly inversely related to fat free mass (? ? 0.2, 95% CI ?0.17, ?0.03, p 0.005).
Conclusions: children with IBD were both under and overweight. Nutritional deficits were more common in Crohn’s disease. Fat free mass was related to disease activity in children with Crohn’s disease regardless of changes in weight. Weight or BMI may mask deficits in lean tissue in the presence of normal or increased proportions of body fat.
Text
__userfiles.soton.ac.uk_Users_nsc_mydesktop_clin nut body comp.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: February 2011
Keywords:
inflammatory bowel disease, body composition, fat free mass, paediatrics
Identifiers
Local EPrints ID: 183297
URI: http://eprints.soton.ac.uk/id/eprint/183297
ISSN: 0261-5614
PURE UUID: 7ab3cd97-f4fe-4a53-a927-d166e742b458
Catalogue record
Date deposited: 03 May 2011 10:23
Last modified: 14 Mar 2024 03:03
Export record
Altmetrics
Contributors
Author:
Anthony E. Wiskin
Author:
Toby M. Hunt
Author:
Victoria R. Cornelius
Author:
Nadeem A. Afzal
Author:
R. Mark Beattie
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics