The University of Southampton
University of Southampton Institutional Repository

Montelukast added to fluticasone propionate does not alter inflammation or outcomes

Djukanović, Ratko, Wilson, Susan J., Moore, Wendy C., Koenig, Steven M., Laviolette, Michel, Bleecker, Eugene, Davis, W. Bruce, Doherty, Dennis E., Olivenstein, Ronald, Israel, Elliot, Kavuru, Mani, Kleerup, Eric, Reilly, Donna S., Yancey, Steven, Edwards, Lisa D., Stauffer, John L., Dorinsky, Paul M. and Jarjour, Nizar N. (2010) Montelukast added to fluticasone propionate does not alter inflammation or outcomes Respiratory Medicine, 104, (10), pp. 1425-1435. (doi:10.1016/j.rmed.2010.04.004). (PMID:20709517).

Record type: Article

Abstract

Background: Airway inflammation is a key pathological feature of asthma which underlies its clinical presentation.

Objectives: To examine whether adding a leukotriene modifier to an inhaled corticosteroid produces further clinical and/or anti-inflammatory benefits in patients symptomatic on short-acting ?2-agonists.

Methods: Patients uncontrolled on short-acting ?2-agonists were treated for 12 weeks with either fluticasone propionate (100 mcg BD) or fluticasone propionate (100 mcg BD) and montelukast (10 mg QD) in a randomized, double-blind, parallel group study. Bronchoscopy with endobronchial biopsy and bronchoalveolar lavage (BAL) was performed before and after treatment to compare effects on airway inflammation.

Results: Of 103 subjects enrolled, 89 subjects completed treatment and 82 subjects had matched pair biopsy samples. Submucosal eosinophil counts, the primary endpoint, and asthma control improved to similar extents after both treatments (p ? 0.008). Both treatments significantly reduced submucosal mast cell, CD3+, CD4+, CD8+ and CD25+ cell counts. Submucosal mast cell reduction was greater in the fluticasone propionate plus montelukast group. There were no differences between treatments in BAL markers of inflammation or thickness of sub-epithelial collagen.

Conclusions: Low-dose fluticasone propionate significantly improves clinical disease control and reduces airway inflammation in asthma patients uncontrolled with short-acting ?2-agonists without further improvement when montelukast is added to low-dose fluticasone propionate.

Full text not available from this repository.

More information

Published date: October 2010
Keywords: asthma, airway inflammation, eosinophils, bronchoscopy, fluticasone propionate, montelukast

Identifiers

Local EPrints ID: 183683
URI: http://eprints.soton.ac.uk/id/eprint/183683
PURE UUID: 4f7f4f33-5ba3-4b6a-9658-4182a5b4c72f
ORCID for Ratko Djukanović: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 03 May 2011 15:03
Last modified: 18 Jul 2017 11:55

Export record

Altmetrics

Contributors

Author: Susan J. Wilson
Author: Wendy C. Moore
Author: Steven M. Koenig
Author: Michel Laviolette
Author: Eugene Bleecker
Author: W. Bruce Davis
Author: Dennis E. Doherty
Author: Ronald Olivenstein
Author: Elliot Israel
Author: Mani Kavuru
Author: Eric Kleerup
Author: Donna S. Reilly
Author: Steven Yancey
Author: Lisa D. Edwards
Author: John L. Stauffer
Author: Paul M. Dorinsky
Author: Nizar N. Jarjour

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×