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Long-term evaluation of the impact of the h1-receptor antagonist cetirizine on the behavioral, cognitive and psychomotor development of very young children with atopic dermatitis

Record type: Article

The impact of the prolonged use of cetirizine at high dose (0.25 mg/kg twice a day over 18 mo) on behavior and cognitive ability was examined in a double-blind, randomized, placebo-controlled trial (ETAC—Early Treatment of the Atopic Child) designed to establish whether it was possible to prevent young children (1–2 y old at study entry) with atopic dermatitis from developing asthma. Well-validated and standardized measures of behavior (Behavior Screening Questionnaire) and cognition (McCarthy Scales of Children’s Abilities) were used. In addition, the ages of attainment of psychomotor milestones were established. These measures were taken between an average of 32 and 53 mo of age, both during the study treatment with cetirizine or placebo and after the study treatment had been discontinued. The Behavior Screening Questionnaire was completed at least once on approximately 300 children in each group and on approximately 200 children on five occasions. The McCarthy Scales of Children’s Abilities were administered to approximately 100 in each group at three different times. There were no significant differences between the cetirizine and placebo groups on either of the behavior and cognition measures or in psychomotor milestones during or after the study treatment. These findings suggest that there are no adverse effects on behavior or learning processes associated with the prolonged use of cetirizine in young children with atopic dermatitis.
Abbreviations:
ETAC, Early Treatment of the Atopic Child
BSQ, Behavior Screening Questionnaire
MSCA, McCarthy Scales of Children’s Abilities
GCI, General Cognitive Index
GMQ, Global Medical Questionnaire

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Citation

Stevenson, Jim, Cornah, Deborah, Evrard, Philippe, Vanderheyden, Valere, Billard, Catherine, Bax, Martin and van Hout, Anne (2002) Long-term evaluation of the impact of the h1-receptor antagonist cetirizine on the behavioral, cognitive and psychomotor development of very young children with atopic dermatitis Pediatric Research, 52, (2), pp. 251-257. (doi:10.1203/01.PDR.0000024060.49308.89).

More information

Published date: 2002

Identifiers

Local EPrints ID: 18373
URI: http://eprints.soton.ac.uk/id/eprint/18373
ISSN: 0031-3998
PURE UUID: 2721eff7-cea0-43c4-abf5-844abbe28abd

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Date deposited: 06 Jan 2006
Last modified: 17 Jul 2017 16:36

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Contributors

Author: Jim Stevenson
Author: Deborah Cornah
Author: Philippe Evrard
Author: Valere Vanderheyden
Author: Catherine Billard
Author: Martin Bax
Author: Anne van Hout

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