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Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy

Record type: Article

Aim: To investigate relationships between hand function, brain lesions, and corticomotor projections in children with unilateral cerebral palsy (CP).

Method: The study included 17 children (nine males, eight females; mean age 11.4 [SD 2.4] range 7–16y), with unilateral CP at Gross Motor Function Classification System level I and Manual Ability Classification System level I or II. Hand function was assessed with the Box and Blocks test and Assisting Hand Assessment (AHA). Conventional structural magnetic resonance images were assessed visually for type, location, and extent of brain lesions. Single-pulse transcranial magnetic stimulation (TMS) provided information on organization of corticomotor projections.

Results: The most favourable hand function was seen in children who had white-matter damage of immaturity with mild white-matter loss and contralateral motor projections. Children with ipsilateral projections had the most impaired function. Nevertheless, in this subgroup a range of ability was seen (AHA 29–59%). Motor-projection patterns appeared to be influenced by lesion extent and location, but not by lesion type.

Interpretation: Combining information from structural magnetic resonance images and TMS can improve prediction of hand function. A wide variation in hand function was seen within all motor-projection patterns. Although the most impaired hand function was seen in the ipsilateral motor-projection group, some children in this group had fairly good ability. Such information is important for treatment planning.

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Citation

Holmstrom, Linda, Tedroff, Kristina, Islam, Mominul, Persson, Jonas K.E., Kits, Annika, Forssberg, Hans and Eliasson, Ann-Christin (2010) Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy Developmental Medicine and Child Neurology, 52, (2), pp. 145-152. (doi:10.1111/j.1469-8749.2009.03496.x). (PMID:19807768).

More information

Published date: February 2010
Organisations: Medicine

Identifiers

Local EPrints ID: 183821
URI: http://eprints.soton.ac.uk/id/eprint/183821
ISSN: 0012-1622
PURE UUID: f3da788a-2ced-42e3-90e8-83ce7bc49a95

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Date deposited: 04 May 2011 09:28
Last modified: 18 Jul 2017 11:55

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Contributors

Author: Linda Holmstrom
Author: Kristina Tedroff
Author: Mominul Islam
Author: Jonas K.E. Persson
Author: Annika Kits
Author: Hans Forssberg
Author: Ann-Christin Eliasson

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