The use of combined single photon emission computed tomography and X-ray computed tomography to assess the fate of inhaled aerosol
The use of combined single photon emission computed tomography and X-ray computed tomography to assess the fate of inhaled aerosol
Background: Gamma camera imaging is widely used to assess pulmonary aerosol deposition. Conventional planar imaging provides limited information on its regional distribution. In this study, single photon emission computed tomography (SPECT) was used to describe deposition in three dimensions (3D) and combined with X-ray computed tomography (CT) to relate this to lung anatomy. Its performance was compared to planar imaging.
Methods: Ten SPECT/CT studies were performed on five healthy subjects following carefully controlled inhalation of radioaerosol from a nebulizer, using a variety of inhalation regimes. The 3D spatial distribution was assessed using a central-to-peripheral ratio (C/P) normalized to lung volume and for the right lung was compared to planar C/P analysis. The deposition by airway generation was calculated for each lung and the conducting airways deposition fraction compared to 24-h clearance.
Results: The 3D normalized C/P ratio correlated more closely with 24-h clearance than the 2D ratio for the right lung [coefficient of variation (COV), 9% compared to 15% p?<?0.05]. Analysis of regional distribution was possible for both lungs in 3D but not in 2D due to overlap of the stomach on the left lung. The mean conducting airways deposition fraction from SPECT for both lungs was not significantly different from 24-h clearance (COV 18%). Both spatial and generational measures of central deposition were significantly higher for the left than for the right lung.
Conclusions: Combined SPECT/CT enabled improved analysis of aerosol deposition from gamma camera imaging compared to planar imaging. 3D radionuclide imaging combined with anatomical information from CT and computer analysis is a useful approach for applications requiring regional information on deposition.
49-60
Fleming, John
9dfe6059-3383-4621-9ef4-4ea221640b55
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Majoral, Caroline
ada299c6-e2be-4020-a612-71605863f2c3
Tossici-Bolt, Livia
a9bd79ee-18c7-40c0-a1a8-2d826e4be759
Katz, Ira
249570b4-914e-44b7-9515-896a827dbb77
Caillibotte, Georges
79fb83bf-a234-48a4-8cb4-1ee6725f7582
Perchet, Diane
1b464d86-f36e-4a08-977a-053d79764ee8
Pichelin, Marine
8beabdf7-5053-4032-a651-60e03c3e6654
Muellinger, Bernhard
3548eff3-db6d-425b-98bc-a321e908e0a1
Martonen, Ted
8ad9a29d-d529-4001-9f7a-b1ced16d447e
Kroneberg, Philipp
1c57b810-7695-407e-bb55-94fe6681f5f1
Apiou-Sbirlea, Gabriela
c1273891-df2b-4a6a-9ae6-c82583cac6d4
January 2011
Fleming, John
9dfe6059-3383-4621-9ef4-4ea221640b55
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Majoral, Caroline
ada299c6-e2be-4020-a612-71605863f2c3
Tossici-Bolt, Livia
a9bd79ee-18c7-40c0-a1a8-2d826e4be759
Katz, Ira
249570b4-914e-44b7-9515-896a827dbb77
Caillibotte, Georges
79fb83bf-a234-48a4-8cb4-1ee6725f7582
Perchet, Diane
1b464d86-f36e-4a08-977a-053d79764ee8
Pichelin, Marine
8beabdf7-5053-4032-a651-60e03c3e6654
Muellinger, Bernhard
3548eff3-db6d-425b-98bc-a321e908e0a1
Martonen, Ted
8ad9a29d-d529-4001-9f7a-b1ced16d447e
Kroneberg, Philipp
1c57b810-7695-407e-bb55-94fe6681f5f1
Apiou-Sbirlea, Gabriela
c1273891-df2b-4a6a-9ae6-c82583cac6d4
Fleming, John, Conway, Joy, Majoral, Caroline, Tossici-Bolt, Livia, Katz, Ira, Caillibotte, Georges, Perchet, Diane, Pichelin, Marine, Muellinger, Bernhard, Martonen, Ted, Kroneberg, Philipp and Apiou-Sbirlea, Gabriela
(2011)
The use of combined single photon emission computed tomography and X-ray computed tomography to assess the fate of inhaled aerosol.
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 (1), .
(doi:10.1089/jamp.2010.0843).
(PMID:21166585)
Abstract
Background: Gamma camera imaging is widely used to assess pulmonary aerosol deposition. Conventional planar imaging provides limited information on its regional distribution. In this study, single photon emission computed tomography (SPECT) was used to describe deposition in three dimensions (3D) and combined with X-ray computed tomography (CT) to relate this to lung anatomy. Its performance was compared to planar imaging.
Methods: Ten SPECT/CT studies were performed on five healthy subjects following carefully controlled inhalation of radioaerosol from a nebulizer, using a variety of inhalation regimes. The 3D spatial distribution was assessed using a central-to-peripheral ratio (C/P) normalized to lung volume and for the right lung was compared to planar C/P analysis. The deposition by airway generation was calculated for each lung and the conducting airways deposition fraction compared to 24-h clearance.
Results: The 3D normalized C/P ratio correlated more closely with 24-h clearance than the 2D ratio for the right lung [coefficient of variation (COV), 9% compared to 15% p?<?0.05]. Analysis of regional distribution was possible for both lungs in 3D but not in 2D due to overlap of the stomach on the left lung. The mean conducting airways deposition fraction from SPECT for both lungs was not significantly different from 24-h clearance (COV 18%). Both spatial and generational measures of central deposition were significantly higher for the left than for the right lung.
Conclusions: Combined SPECT/CT enabled improved analysis of aerosol deposition from gamma camera imaging compared to planar imaging. 3D radionuclide imaging combined with anatomical information from CT and computer analysis is a useful approach for applications requiring regional information on deposition.
Text
The_use_of_combined_single_photon.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: January 2011
Organisations:
Health Sciences
Identifiers
Local EPrints ID: 184075
URI: http://eprints.soton.ac.uk/id/eprint/184075
ISSN: 1941-2711
PURE UUID: 9d2fc7aa-1fd8-4dc4-94e7-f2806c21152f
Catalogue record
Date deposited: 05 May 2011 08:38
Last modified: 14 Mar 2024 03:06
Export record
Altmetrics
Contributors
Author:
John Fleming
Author:
Joy Conway
Author:
Caroline Majoral
Author:
Livia Tossici-Bolt
Author:
Ira Katz
Author:
Georges Caillibotte
Author:
Diane Perchet
Author:
Marine Pichelin
Author:
Bernhard Muellinger
Author:
Ted Martonen
Author:
Philipp Kroneberg
Author:
Gabriela Apiou-Sbirlea
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics