The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results
The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results
Study using data from the UK General Practice Research Database on 244,235 oral corticosteroid users and 244,235 controls. Validation of fractures showed that hip fractures were confirmed by GPs on the questionnaire in 90.7% of the cases and by discharge summary in 86.5%. The relative rate of non-vertebral fracture during oral corticosteroid use did not vary substantially between patients with different diseases, age, or gender. The sensitivity analysis, modifying the type of analysis or inclusion of patients, did not materially change the findings.
oral corticosteroids, fractures, methods
359-366
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Abenhaim, L.
98b3a822-aed6-4c7d-bfbf-292b6b11134a
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Zhang, B.
0944e483-9118-4f70-9815-acdcad5dfeec
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
September 2000
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Abenhaim, L.
98b3a822-aed6-4c7d-bfbf-292b6b11134a
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Zhang, B.
0944e483-9118-4f70-9815-acdcad5dfeec
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Van Staa, T.P., Abenhaim, L., Cooper, C., Zhang, B. and Leufkens, H.G.
(2000)
The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results.
Pharmacoepidemiology and Drug Safety, 9 (5), .
(doi:10.1002/1099-1557(200009/10)9:5<359::AID-PDS507>3.0.CO;2-E).
(PMID:19025840)
Abstract
Study using data from the UK General Practice Research Database on 244,235 oral corticosteroid users and 244,235 controls. Validation of fractures showed that hip fractures were confirmed by GPs on the questionnaire in 90.7% of the cases and by discharge summary in 86.5%. The relative rate of non-vertebral fracture during oral corticosteroid use did not vary substantially between patients with different diseases, age, or gender. The sensitivity analysis, modifying the type of analysis or inclusion of patients, did not materially change the findings.
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Published date: September 2000
Keywords:
oral corticosteroids, fractures, methods
Identifiers
Local EPrints ID: 184151
URI: http://eprints.soton.ac.uk/id/eprint/184151
ISSN: 1053-8569
PURE UUID: 1ac27700-cfa4-435c-98f8-0577fb436e40
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Date deposited: 05 May 2011 10:08
Last modified: 18 Mar 2024 02:45
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Contributors
Author:
T.P. Van Staa
Author:
L. Abenhaim
Author:
B. Zhang
Author:
H.G. Leufkens
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