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The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results

Record type: Article

Study using data from the UK General Practice Research Database on 244,235 oral corticosteroid users and 244,235 controls. Validation of fractures showed that hip fractures were confirmed by GPs on the questionnaire in 90.7% of the cases and by discharge summary in 86.5%. The relative rate of non-vertebral fracture during oral corticosteroid use did not vary substantially between patients with different diseases, age, or gender. The sensitivity analysis, modifying the type of analysis or inclusion of patients, did not materially change the findings.

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Citation

Van Staa, T.P., Abenhaim, L., Cooper, C., Zhang, B. and Leufkens, H.G. (2000) The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results Pharmacoepidemiology and Drug Safety, 9, (5), pp. 359-366. (doi:10.1002/1099-1557(200009/10)9:5<359::AID-PDS507>3.0.CO;2-E). (PMID:19025840).

More information

Published date: September 2000
Keywords: oral corticosteroids, fractures, methods

Identifiers

Local EPrints ID: 184151
URI: http://eprints.soton.ac.uk/id/eprint/184151
ISSN: 1053-8569
PURE UUID: 1ac27700-cfa4-435c-98f8-0577fb436e40

Catalogue record

Date deposited: 05 May 2011 10:08
Last modified: 18 Jul 2017 11:52

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Contributors

Author: T.P. Van Staa
Author: L. Abenhaim
Author: C. Cooper
Author: B. Zhang
Author: H.G. Leufkens

University divisions

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