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Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database

Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database
Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database
In October 1995 the Committee on Safety of Medicines advised UK doctors and pharmacists that oral contraceptives containing desogestrel and gestodene were associated with double the risk of venous thromboembolic events (VTE) compared to pills containing other progestogens. In 1997 data was analysed from the MediPlus database of UK general practitioner records, which reported odds ratios for desogestrel and gestodene lower than that for levonorgestrel. Here the results of a more stringent nested case control analysis on the MediPlus database are reported. The study was larger and cases were verified. A crude incidence of idiopathic VTE was found amongst users of combined oral contraceptives of 4.6 per 10 000 exposed women years. Using levonorgestrel 150 ?g + ethinyloestradiol 30 ?g as reference, non-significant odds ratios of 1.1 (0.5–2.6) for desogestrel 150 ?g + ethinyloestradiol 30 ?g and 1.1 (0.5–2.4) for gestodene 75 ?g + ethinyloestradiol 30 ?g were found. The results of this study show no significant difference in risk between different formulations of combined oral contraceptive.
case control, oral contraceptives, pill scare, study mediplus databaes, venous thromboembolic disease
1500-1505
Todd, J.C.
dc92bc33-5a6e-4914-a8a7-8bb6e92abcc9
Lawrenson, R.
869deb36-de86-459b-a2ad-002426d9537e
Farmer, R.D.
16d17ff1-a66a-4f66-a4b3-cf5fd07a0655
Williams, T.J.
99d7e758-9705-4f86-a68b-ace614309bf4
Leydon, G.M.
c5cdaff5-0fa1-4d38-b575-b97c2892ec40
Todd, J.C.
dc92bc33-5a6e-4914-a8a7-8bb6e92abcc9
Lawrenson, R.
869deb36-de86-459b-a2ad-002426d9537e
Farmer, R.D.
16d17ff1-a66a-4f66-a4b3-cf5fd07a0655
Williams, T.J.
99d7e758-9705-4f86-a68b-ace614309bf4
Leydon, G.M.
c5cdaff5-0fa1-4d38-b575-b97c2892ec40

Todd, J.C., Lawrenson, R., Farmer, R.D., Williams, T.J. and Leydon, G.M. (1999) Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database. Human Reproduction, 14 (6), 1500-1505. (doi:10.1093/humrep/14.6.1500). (PMID:10357966)

Record type: Article

Abstract

In October 1995 the Committee on Safety of Medicines advised UK doctors and pharmacists that oral contraceptives containing desogestrel and gestodene were associated with double the risk of venous thromboembolic events (VTE) compared to pills containing other progestogens. In 1997 data was analysed from the MediPlus database of UK general practitioner records, which reported odds ratios for desogestrel and gestodene lower than that for levonorgestrel. Here the results of a more stringent nested case control analysis on the MediPlus database are reported. The study was larger and cases were verified. A crude incidence of idiopathic VTE was found amongst users of combined oral contraceptives of 4.6 per 10 000 exposed women years. Using levonorgestrel 150 ?g + ethinyloestradiol 30 ?g as reference, non-significant odds ratios of 1.1 (0.5–2.6) for desogestrel 150 ?g + ethinyloestradiol 30 ?g and 1.1 (0.5–2.4) for gestodene 75 ?g + ethinyloestradiol 30 ?g were found. The results of this study show no significant difference in risk between different formulations of combined oral contraceptive.

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More information

Published date: June 1999
Keywords: case control, oral contraceptives, pill scare, study mediplus databaes, venous thromboembolic disease

Identifiers

Local EPrints ID: 184367
URI: http://eprints.soton.ac.uk/id/eprint/184367
PURE UUID: 4e4ecd4d-60e4-4ea9-831c-c99b1acfc0ba
ORCID for G.M. Leydon: ORCID iD orcid.org/0000-0001-5986-3300

Catalogue record

Date deposited: 05 May 2011 14:39
Last modified: 15 Mar 2024 03:23

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Contributors

Author: J.C. Todd
Author: R. Lawrenson
Author: R.D. Farmer
Author: T.J. Williams
Author: G.M. Leydon ORCID iD

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