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GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors

GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors
GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors
Understanding how neural activity is functionally linked to the stem cell niche, is assuming ever increasing importance as hippocampal neurogenesis is shown to be important for modulating the behavioural responses to stress and for certain forms of learning and memory. Neuropeptides such as neuropeptide Y and vasoactive intestinal peptide have emerged as important mediators for signalling local interneuron activity to subgranular zone precursors, however, little is known regarding the effects of neuropeptides that are extrinsic modulators of hippocampal information processing. Here, we show that the galanin GalR2/3 agonist Gal2-11 is both trophic and proliferative for postnatal subgranular precursors and proliferating neuroblasts at 10?nM and is purely trophic at doses as low as 100?pM. We found no effect mediated via GalR1. As galanin is co-released from noradrenergic and serotonergic projection neurons to the dentate gyrus, these findings support a direct effect of galanin on hippocampal neurogenesis, which may partly mediate its antidepressant effect via GalR2/3 receptors.
dentate gyrus, galanin, galanin receptor-2/3, neurogenesis, prox-1
0022-3042
425-436
Abbosh, Christopher
fa7d12fb-1e6e-4924-ad08-4be6b422278e
Lawkowski, Alexandra
5aaaffd3-46e6-42c1-8328-16c55ad7d2c2
Zaben, Malik
6390c24c-4458-486d-9188-3afda5c91359
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702
Abbosh, Christopher
fa7d12fb-1e6e-4924-ad08-4be6b422278e
Lawkowski, Alexandra
5aaaffd3-46e6-42c1-8328-16c55ad7d2c2
Zaben, Malik
6390c24c-4458-486d-9188-3afda5c91359
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702

Abbosh, Christopher, Lawkowski, Alexandra, Zaben, Malik and Gray, William (2011) GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. Journal of Neurochemistry, 117 (3), 425-436. (doi:10.1111/j.1471-4159.2011.07204.x). (PMID:21281311)

Record type: Article

Abstract

Understanding how neural activity is functionally linked to the stem cell niche, is assuming ever increasing importance as hippocampal neurogenesis is shown to be important for modulating the behavioural responses to stress and for certain forms of learning and memory. Neuropeptides such as neuropeptide Y and vasoactive intestinal peptide have emerged as important mediators for signalling local interneuron activity to subgranular zone precursors, however, little is known regarding the effects of neuropeptides that are extrinsic modulators of hippocampal information processing. Here, we show that the galanin GalR2/3 agonist Gal2-11 is both trophic and proliferative for postnatal subgranular precursors and proliferating neuroblasts at 10?nM and is purely trophic at doses as low as 100?pM. We found no effect mediated via GalR1. As galanin is co-released from noradrenergic and serotonergic projection neurons to the dentate gyrus, these findings support a direct effect of galanin on hippocampal neurogenesis, which may partly mediate its antidepressant effect via GalR2/3 receptors.

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More information

Published date: May 2011
Keywords: dentate gyrus, galanin, galanin receptor-2/3, neurogenesis, prox-1

Identifiers

Local EPrints ID: 184599
URI: https://eprints.soton.ac.uk/id/eprint/184599
ISSN: 0022-3042
PURE UUID: 9f123e57-883a-47e2-a123-2b1a74df4bf4

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Date deposited: 06 May 2011 08:17
Last modified: 18 Jul 2017 11:51

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