The University of Southampton
University of Southampton Institutional Repository

Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease

Record type: Article

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in children and adolescents in industrialized countries. It is important to accurately determine the stage of fibrosis in these patients. The enhanced liver fibrosis (ELF) test has been validated for staging liver fibrosis in adult patients with chronic liver diseases, including NAFLD. We investigated the performance of this test in assessing liver fibrosis in children and adolescents with NAFLD, identified by biopsy.

Methods: The ELF test was performed on a panel of serum samples collected from 112 consecutive subjects that were likely to have NAFLD (64 male, mean age of 13.8 ± 3.3). A previously described and validated algorithm was used to analyze the data on hyaluronic acid (HA), amino-terminal propeptide of type III collagen (PIIINP), and tissue inhibitor of metalloproteinase 1 (TIMP-1) levels.

Results: In pediatric patients with NAFLD, the ELF test predicted liver fibrosis stage with a high degree of sensitivity and specificity; results were superior to those reported for adults. The area under receiver operating characteristic curves/best possible ELF test cut-off values for the prediction of “any” (?stage 1), moderate-perisinusoidal (?stage 1b), moderate-portal/periportal (?stage 1c), significant (?stage 2), or advanced (?stage 3) fibrosis were 0.92/9.28, 0.92/9.33, 0.90/9.54, 0.98/10.18 and 0.99/10.51, respectively.

Conclusions: The ELF test can be used to accurately assess the level of liver fibrosis in pediatric patients with NAFLD. This information is important for identifying patients with progressive fibrosis that require further histopathological analysis or therapeutic follow-up.

Full text not available from this repository.

Citation

Nobili, Valerio, Parkes, Julie, Bottazzo, Gianfranco, Marcellini, Matilde, Cross, Richard, Newman, Daniel, Vizzutti, Francesco, Pinzani, Massimo and Rosenberg, William M. (2009) Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease Gastroenterology, 136, (1), pp. 160-167. (doi:10.1053/j.gastro.2008.09.013). (PMID:18992746).

More information

Published date: January 2009
Organisations: Community Clinical Sciences

Identifiers

Local EPrints ID: 185093
URI: http://eprints.soton.ac.uk/id/eprint/185093
ISSN: 0016-5085
PURE UUID: 955437a2-4663-4bef-a477-3a088d746515

Catalogue record

Date deposited: 09 May 2011 10:54
Last modified: 18 Jul 2017 11:50

Export record

Altmetrics

Contributors

Author: Valerio Nobili
Author: Julie Parkes
Author: Gianfranco Bottazzo
Author: Matilde Marcellini
Author: Richard Cross
Author: Daniel Newman
Author: Francesco Vizzutti
Author: Massimo Pinzani
Author: William M. Rosenberg

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×