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The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial

Mutsaerts, Meike A.Q., Groen, Henk, ter Bogt, Nancy C.W., Bolster, Johanna H.T., Land, Jolande A., Bemelmans, Wanda J.E., Kuchenbecker, Walter K.H., Hompes, Peter G.A., Macklon, Nick S., Stolk, Ronald P., van der Veen, Fulco, Maas, Jacques W.M., Klijn, Nicole F., Kaaijk, Eugenie M., Oosterhuis, Gerrit J.E., Bouckaert, Peter X.J.M., Schierbeek, Jaap M., van Kasteren, Yvonne M., Nap, Annemiek W., Broekmans, Frank J., Brinkhuis, Egbert A., Koks, Carolien A.M., Burggraaff, Jan M., Blankhart, Adrienne S., Perquin, Denise A., Gerards, Marie H., Mulder, Robery J.A.B., Gondrie, Ed T.C.M., Mol, Ben W.J. and Hoek, Annemieke (2010) The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial BMC Womens Health, 10, p. 22. (doi:10.1186/1472-6874-10-22). (PMID:20579357).

Record type: Article

Abstract

Background: In the Netherlands, 30% of subfertile women are overweight or obese, and at present there is no agreement on fertility care for them. Data from observational and small intervention studies suggest that reduction of weight will increase the chances of conception, decrease pregnancy complications and improve perinatal outcome, but this has not been confirmed in randomised controlled trials. This study will assess the cost and effects of a six-months structured lifestyle program aiming at weight reduction followed by conventional fertility care (intervention group) as compared to conventional fertility care only (control group) in overweight and obese subfertile women. We hypothesize that the intervention will decrease the need for fertility treatment, diminish overweight-related pregnancy complications, and will improve perinatal outcome.

Methods/Design: Multicenter randomised controlled trial in subfertile women (age 18-39 year) with a body mass index between 29 and 40 kg/m2. Exclusion criteria are azoospermia, use of donor semen, severe endometriosis, premature ovarian failure, endocrinopathies or pre-existent hypertensive disorders.

In the intervention group the aim is a weight loss of at least 5% to10% in a six-month period, to be achieved by the combination of a diet, increase of physical activity and behavioural modification. After six months, in case no conception has been achieved, these patients will start fertility treatment according to the Dutch fertility guidelines. In the control group treatment will be started according to Dutch fertility guidelines, independently of the patient's weight.

Outcome measures and analysis: The primary outcome measure is a healthy singleton born after at least 37 weeks of gestation after vaginal delivery. Secondary outcome parameters including pregnancy outcome and complications, percentage of women needing fertility treatment, clinical and ongoing pregnancy rates, body weight, quality of life and costs.

Data will be analysed according to the intention to treat principle, and cost-effectiveness analysis will be performed to compare the costs and health effects in the intervention and control group.

Discussion: The trial will provide evidence for costs and effects of a lifestyle intervention aiming at weight reduction in overweight and obese subfertile women and will offer guidance to clinicians for the treatment of these patients.

Trial registration:Dutch Trial Register NTR1530

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Published date: June 2010

Identifiers

Local EPrints ID: 185245
URI: http://eprints.soton.ac.uk/id/eprint/185245
PURE UUID: 7f2bb598-5f6d-4675-bb87-a382d6e2190a

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Date deposited: 10 May 2011 09:07
Last modified: 18 Jul 2017 11:49

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Contributors

Author: Meike A.Q. Mutsaerts
Author: Henk Groen
Author: Nancy C.W. ter Bogt
Author: Johanna H.T. Bolster
Author: Jolande A. Land
Author: Wanda J.E. Bemelmans
Author: Walter K.H. Kuchenbecker
Author: Peter G.A. Hompes
Author: Nick S. Macklon
Author: Ronald P. Stolk
Author: Fulco van der Veen
Author: Jacques W.M. Maas
Author: Nicole F. Klijn
Author: Eugenie M. Kaaijk
Author: Gerrit J.E. Oosterhuis
Author: Peter X.J.M. Bouckaert
Author: Jaap M. Schierbeek
Author: Yvonne M. van Kasteren
Author: Annemiek W. Nap
Author: Frank J. Broekmans
Author: Egbert A. Brinkhuis
Author: Carolien A.M. Koks
Author: Jan M. Burggraaff
Author: Adrienne S. Blankhart
Author: Denise A. Perquin
Author: Marie H. Gerards
Author: Robery J.A.B. Mulder
Author: Ed T.C.M. Gondrie
Author: Ben W.J. Mol
Author: Annemieke Hoek

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