Heijnen, Esther M. E. W., Eijkemans, Marinus J. C., De Klerk, Cora, Polinder, Suzanne, Beckers, Nicole G. M., Klinkert, Ellen R., Broekmans, Frank J., Passchier, Jan, Te Velde, Egbert R., Macklon, Nick S. and Fauser, Bart C. J. M.
A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial
Lancet, 369, (9563), . (PMID:18491824).
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Over 1 year of treatment, cumulative rates of term livebirths and patients' discomfort are much the same for mild ovarian stimulation with single embryos transferred and for standard stimulation with two embryos transferred. However, a mild IVF treatment protocol can substantially reduce multiple pregnancy rates and overall costs.
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