The University of Southampton
University of Southampton Institutional Repository

A case study of the applicability of a prediction model for the selection of patients undergoing in vitro fertilization for single embryo transfer in another center

Hunault, Claudine C., te Velde, Egbert R., Weima, Sjerp M., Macklon, Nicholas S., Eijkemans, Marinus J. C., Klinkert, Ellen R. and Habbema, J. Dik F. (2007) A case study of the applicability of a prediction model for the selection of patients undergoing in vitro fertilization for single embryo transfer in another center Fertility and Sterility, 87, (6), pp. 1314-1321. (doi:10.1016/j.fertnstert.2006.11.052). (PMID:17307175).

Record type: Article

Abstract

Objective: To evaluate the application in a different fertility clinic of a prediction model for selecting IVF patients
for elective single embryo transfer.

Design: Retrospective analysis of a large database obtained from a tertiary infertility center.

Setting: University medical center.

Patient(s): The model, derived at the “development center” was applied in 494 consecutive first IVF cycles
carried out at the “application center.”

Intervention(s): After adjustment of embryo scoring system to be compatible with that used by the prediction
model, it was applied to the development center data. A score chart for predicting the probability of singleton or
twin pregnancy was constructed.

Main Outcome Measure(s): The area under the receiver operator curve (ROC) was determined to measure the
ability of the model to discriminate between ongoing pregnancy and twin pregnancy. Calibration plots were made
to assess agreement between predicted and observed pregnancy rates (PR).

Results: The areas under the ROC for predicting ongoing pregnancy and twin pregnancy were 0.63 and 0.66,
respectively. Insertion of a correction factor equivalent to the difference in odds ratios for ongoing PR between
the two centers was required to improve the calibration of the model.

Conclusion(s): After adaptation, the model performed well in the application center.

Full text not available from this repository.

More information

Published date: June 2007
Keywords: external validation, ivf, prediction model, elective single embryo transfer

Identifiers

Local EPrints ID: 185473
URI: http://eprints.soton.ac.uk/id/eprint/185473
ISSN: 0015-0282
PURE UUID: 689ed706-db41-4dcc-9b7e-03e2eb55a173

Catalogue record

Date deposited: 11 May 2011 09:24
Last modified: 18 Jul 2017 11:49

Export record

Altmetrics

Contributors

Author: Claudine C. Hunault
Author: Egbert R. te Velde
Author: Sjerp M. Weima
Author: Marinus J. C. Eijkemans
Author: Ellen R. Klinkert
Author: J. Dik F. Habbema

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×