The University of Southampton
University of Southampton Institutional Repository

Optimum number of oocytes for a successful first IVF treatment cycle

Record type: Article

Ovarian stimulation in IVF allows selection of embryos for transfer, but may have detrimental effects on oocyte and embryo quality and endometrial receptivity. This study investigated the optimal response to ovarian stimulation in terms of number of oocytes for achieving pregnancy in a first IVF cycle. Data from 7422 women who underwent their first IVF cycle for standard indications were analysed. All had been treated with exogenous gonadotrophins and gonadotrophin releasing hormone (GnRH) agonist co-treatment in a long down-regulation protocol between 1990 and 1995. Pregnancy rates in relation to the number of obtained oocytes were adjusted for age, fecundity, subfertility cause, gonadotrophin dosage, type of luteal support, and number of transferred embryos by multivariate analysis. Of the 7422 women who underwent oocyte retrieval, overall 85% had an embryo transfer and 24% conceived. The highest pregnancy rates per embryo transfer and per started cycle were observed when 13 oocytes were obtained (31 and 28%, respectively). This study supports the concept of an optimal range of oocytes obtained in response to ovarian stimulation for IVF, below and above which outcomes are compromised.

Full text not available from this repository.

Citation

van der Gaast, M.H., Eijkemans, M.J.C., van der Net, J.B., de Boer, E.J., Burger, C.W., van Leeuwen, F.E., Fauser, B.C.J.M. and Macklon, N.S. (2006) Optimum number of oocytes for a successful first IVF treatment cycle Reproductive Biomedicine Online, 13, (4), pp. 476-480. (doi:10.1016/S1472-6483(10)60633-5). (PMID:17007663).

More information

Published date: October 2006
Keywords: ivf, oocytes, optimum, ovarian stimulation, pregnancy

Identifiers

Local EPrints ID: 185535
URI: http://eprints.soton.ac.uk/id/eprint/185535
ISSN: 1472-6483
PURE UUID: 3639fb44-39b6-4607-83d6-c994937fc550

Catalogue record

Date deposited: 18 May 2011 12:37
Last modified: 18 Jul 2017 11:49

Export record

Altmetrics

Contributors

Author: M.H. van der Gaast
Author: M.J.C. Eijkemans
Author: J.B. van der Net
Author: E.J. de Boer
Author: C.W. Burger
Author: F.E. van Leeuwen
Author: B.C.J.M. Fauser
Author: N.S. Macklon

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×