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Optimum number of oocytes for a successful first IVF treatment cycle

van der Gaast, M.H., Eijkemans, M.J.C., van der Net, J.B., de Boer, E.J., Burger, C.W., van Leeuwen, F.E., Fauser, B.C.J.M. and Macklon, N.S. (2006) Optimum number of oocytes for a successful first IVF treatment cycle Reproductive Biomedicine Online, 13, (4), pp. 476-480. (doi:10.1016/S1472-6483(10)60633-5). (PMID:17007663).

Record type: Article


Ovarian stimulation in IVF allows selection of embryos for transfer, but may have detrimental effects on oocyte and embryo quality and endometrial receptivity. This study investigated the optimal response to ovarian stimulation in terms of number of oocytes for achieving pregnancy in a first IVF cycle. Data from 7422 women who underwent their first IVF cycle for standard indications were analysed. All had been treated with exogenous gonadotrophins and gonadotrophin releasing hormone (GnRH) agonist co-treatment in a long down-regulation protocol between 1990 and 1995. Pregnancy rates in relation to the number of obtained oocytes were adjusted for age, fecundity, subfertility cause, gonadotrophin dosage, type of luteal support, and number of transferred embryos by multivariate analysis. Of the 7422 women who underwent oocyte retrieval, overall 85% had an embryo transfer and 24% conceived. The highest pregnancy rates per embryo transfer and per started cycle were observed when 13 oocytes were obtained (31 and 28%, respectively). This study supports the concept of an optimal range of oocytes obtained in response to ovarian stimulation for IVF, below and above which outcomes are compromised.

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Published date: October 2006
Keywords: ivf, oocytes, optimum, ovarian stimulation, pregnancy


Local EPrints ID: 185535
ISSN: 1472-6483
PURE UUID: 3639fb44-39b6-4607-83d6-c994937fc550

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Date deposited: 18 May 2011 12:37
Last modified: 18 Jul 2017 11:49

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Author: M.H. van der Gaast
Author: M.J.C. Eijkemans
Author: J.B. van der Net
Author: E.J. de Boer
Author: C.W. Burger
Author: F.E. van Leeuwen
Author: B.C.J.M. Fauser
Author: N.S. Macklon

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