The science behind 25 years of ovarian stimulation for in vitro fertilization

Macklon, Nick S., Stouffer, Richard L., Giudice, Linda C. and Fauser, Bart C. J. M. (2006) The science behind 25 years of ovarian stimulation for in vitro fertilization Endocrine Reviews, 27, (2), pp. 170-207. (doi:10.1210/er.2005-0015). (PMID:16434510).


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To allow selection of embryos for transfer after in vitro fertilization, ovarian stimulation is usually carried out with exogenous gonadotropins. To compensate for changes induced by stimulation, GnRH analog cotreatment, oral contraceptive pretreatment, late follicular phase human chorionic gonadotropin, and luteal phase progesterone supplementation are usually added. These approaches render ovarian stimulation complex and costly. The stimulation of multiple follicular development disrupts the physiology of follicular development, with consequences for the oocyte, embryo, and endometrium. In recent years, recombinant gonadotropin preparations have become available, and novel stimulation protocols with less detrimental effects have been developed. In this article, the scientific background to current approaches to ovarian stimulation for in vitro fertilization is reviewed. After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1210/er.2005-0015
ISSNs: 1945-7189 (print)
Related URLs:
ePrint ID: 185623
Date :
Date Event
1 April 2006Published
Date Deposited: 19 May 2011 12:49
Last Modified: 18 Apr 2017 02:16
Further Information:Google Scholar

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