The University of Southampton
University of Southampton Institutional Repository

The science behind 25 years of ovarian stimulation for in vitro fertilization

Macklon, Nick S., Stouffer, Richard L., Giudice, Linda C. and Fauser, Bart C. J. M. (2006) The science behind 25 years of ovarian stimulation for in vitro fertilization Endocrine Reviews, 27, (2), pp. 170-207. (doi:10.1210/er.2005-0015). (PMID:16434510).

Record type: Article

Abstract

To allow selection of embryos for transfer after in vitro fertilization, ovarian stimulation is usually carried out with exogenous gonadotropins. To compensate for changes induced by stimulation, GnRH analog cotreatment, oral contraceptive pretreatment, late follicular phase human chorionic gonadotropin, and luteal phase progesterone supplementation are usually added. These approaches render ovarian stimulation complex and costly. The stimulation of multiple follicular development disrupts the physiology of follicular development, with consequences for the oocyte, embryo, and endometrium. In recent years, recombinant gonadotropin preparations have become available, and novel stimulation protocols with less detrimental effects have been developed. In this article, the scientific background to current approaches to ovarian stimulation for in vitro fertilization is reviewed. After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail.

Full text not available from this repository.

More information

Published date: 1 April 2006

Identifiers

Local EPrints ID: 185623
URI: http://eprints.soton.ac.uk/id/eprint/185623
ISSN: 1945-7189
PURE UUID: f0a8341a-f531-4ce9-9501-2a256d8b4c24

Catalogue record

Date deposited: 19 May 2011 12:49
Last modified: 18 Jul 2017 11:49

Export record

Altmetrics

Contributors

Author: Nick S. Macklon
Author: Richard L. Stouffer
Author: Linda C. Giudice
Author: Bart C. J. M. Fauser

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×