The University of Southampton
University of Southampton Institutional Repository

The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF

de Klerk, C., Heijnen, E.M.E.W., Macklon, N.S., Duivenvoorden, H.J., Fauser, B.C.J.M., Passchier, J. and Hunfeld, J.A.M. (2006) The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF Human Reproduction, 21, (3), pp. 721-727. (doi:10.1093/humrep/dei395). (PMID:16311295).

Record type: Article

Abstract

Background: The objective of this study was to assess the psychological implications of mild ovarian stimulation combined with single embryo transfer (SET) during a first IVF cycle.

Methods: We conducted a randomized controlled two-centre trial. Three hundred and ninety-one couples were randomized to undergo either mild ovarian stimulation with GnRH antagonist co-treatment and SET (n = 199) or conventional GnRH agonist long protocol ovarian stimulation with double embryo transfer (DET) (n = 192). Women completed the Hospital Anxiety and Depression Scale, the Hopkins Symptom Checklist and the Subjective Sleep Quality Scale at baseline, on the first day of ovarian stimulation and following embryo transfer. Affect was assessed daily with the Daily Record Keeping Chart from the first day of ovarian stimulation until the day treatment outcome became known.

Results: The conventional IVF group experienced elevated levels of physical and depressive symptoms during pituitary downregulation. At oocyte retrieval, this group experienced more positive affect and less negative affect than the mild IVF group. In the conventional IVF group, cycle cancellation was associated with less positive and more negative affect.

Conclusions: During the first IVF treatment cycle, mild ovarian stimulation and SET does not lead to more psychological complaints than conventional IVF.

Full text not available from this repository.

More information

Published date: March 2006

Identifiers

Local EPrints ID: 185625
URI: http://eprints.soton.ac.uk/id/eprint/185625
PURE UUID: 72143766-9fab-42a3-b30c-ddf8407ad263

Catalogue record

Date deposited: 19 May 2011 12:46
Last modified: 18 Jul 2017 11:49

Export record

Altmetrics

Contributors

Author: C. de Klerk
Author: E.M.E.W. Heijnen
Author: N.S. Macklon
Author: H.J. Duivenvoorden
Author: B.C.J.M. Fauser
Author: J. Passchier
Author: J.A.M. Hunfeld

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×