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Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF

Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF
Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF
The rates of mosaicism and aneuploidy in these embryos from young IVF patients are similar to those published for older women. We found the best confirmation rate after a diagnosis based on two cells, where both blastomeres showed the same chromosomal abnormality. In contrast, after a mosaic diagnosis the confirmation rate was low. The present study provides the first detailed reanalysis data of embryos analysed by PGS and clearly demonstrates the impact of mosaicism on the reliability of the PGS diagnosis.
aneuploidy, chromosomal mosaicism, confirmation of diagnosis, human preimplantation embryos, preimplantation genetic screening
223-233
Baart, E. B
740d315c-c603-4d81-bf68-431bc88e7079
Martini, E.
dae27c62-1366-428f-b977-3c8bd107b60d
van den Berg, I.
730aff98-8eca-4aa7-9671-76b2081ff32a
Macklon, N. S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Galjaard, R-J. H.
35928cf9-ec30-4ebc-9994-e500f45ea774
Fauser, B. C. J. M.
c65d9f08-b6a6-420b-b2db-71ea7e3c4a8f
Van Opstal, D
2fe3ae4a-e958-476a-84ea-39033718115d
Baart, E. B
740d315c-c603-4d81-bf68-431bc88e7079
Martini, E.
dae27c62-1366-428f-b977-3c8bd107b60d
van den Berg, I.
730aff98-8eca-4aa7-9671-76b2081ff32a
Macklon, N. S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Galjaard, R-J. H.
35928cf9-ec30-4ebc-9994-e500f45ea774
Fauser, B. C. J. M.
c65d9f08-b6a6-420b-b2db-71ea7e3c4a8f
Van Opstal, D
2fe3ae4a-e958-476a-84ea-39033718115d

Baart, E. B, Martini, E., van den Berg, I., Macklon, N. S., Galjaard, R-J. H., Fauser, B. C. J. M. and Van Opstal, D (2006) Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Human Reproduction, 21 (1), 223-233. (doi:10.1093/humrep/dei291). (PMID:16155075)

Record type: Article

Abstract

The rates of mosaicism and aneuploidy in these embryos from young IVF patients are similar to those published for older women. We found the best confirmation rate after a diagnosis based on two cells, where both blastomeres showed the same chromosomal abnormality. In contrast, after a mosaic diagnosis the confirmation rate was low. The present study provides the first detailed reanalysis data of embryos analysed by PGS and clearly demonstrates the impact of mosaicism on the reliability of the PGS diagnosis.

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Published date: January 2006
Keywords: aneuploidy, chromosomal mosaicism, confirmation of diagnosis, human preimplantation embryos, preimplantation genetic screening

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Local EPrints ID: 185627
URI: https://eprints.soton.ac.uk/id/eprint/185627
PURE UUID: cc4de8ea-4182-456b-87e5-c1c3fa465d63

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Date deposited: 19 May 2011 13:03
Last modified: 18 Jul 2017 11:49

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Contributors

Author: E. B Baart
Author: E. Martini
Author: I. van den Berg
Author: N. S. Macklon
Author: R-J. H. Galjaard
Author: B. C. J. M. Fauser
Author: D Van Opstal

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