First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization

Beckers, Nicole G.M., Macklon, Nicholas S., Devroey, Paul, Platteau, Peter, Boerrigter, Peter J. and Fauser, Bart C.J.M. (2003) First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization. Fertility and Sterility, 79 (3), 621-623. (doi:10.1016/S0015-0282(02)04804-5). (PMID:12620451)

Abstract

Objective: To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF.

Design: Case report.

Setting: Tertiary fertility center.

Patient: A 32-year-old woman with a 7-year history of primary infertility.

Intervention: Ovarian stimulation with a single SC injection of 180 ?g recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG.

Main outcome measure: First ongoing pregnancy obtained with recFSH-CTP.

Result: Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks.

Conclusion: The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.

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