Beckers, Nicole G.M., Macklon, Nicholas S., Devroey, Paul, Platteau, Peter, Boerrigter, Peter J. and Fauser, Bart C.J.M.
First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization
Fertility and Sterility, 79, (3), . (doi:10.1016/S0015-0282(02)04804-5). (PMID:12620451).
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Objective: To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF.
Design: Case report.
Setting: Tertiary fertility center.
Patient: A 32-year-old woman with a 7-year history of primary infertility.
Intervention: Ovarian stimulation with a single SC injection of 180 ?g recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG.
Main outcome measure: First ongoing pregnancy obtained with recFSH-CTP.
Result: Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks.
Conclusion: The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.
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