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Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging

Record type: Article

Objective: To investigate whether follicular phase characteristics associated with ovarian aging can be observed in women of normal reproductive age, who had previously shown a poor response to ovarian hyperstimulation for IVF.

Design: Observational, prospective study.

Setting: Tertiary fertility center.

Patient(s): Eleven regularly cycling, ovulatory women, aged 29–40 years who previously presented with fewer than four dominant follicles after ovarian hyperstimulation for IVF.

Intervention(s): Frequent serum hormone assessments and transvaginal ultrasound during the follicular phase of a spontaneous, unstimulated cycle.

Main Outcome Measure(s): Duration of the follicular phase; serum LH, FSH, E2, P, inhibin A, and inhibin B levels; and number of antral follicles observed by ultrasound. Results were compared with the cycle characteristics of a reference population of 38 healthy normo-ovulatory women aged 20–36 years (as published elsewhere).

Result(s): Poor responders had significantly fewer antral follicles than controls. Median FSH concentrations were significantly higher compared with controls, but the majority had FSH levels within the normal range. Follicular phase P levels were significantly higher in poor responders. Duration of the follicular phase, E2, and inhibin A and inhibin B serum levels did not differ between poor responders and controls.

Conclusion(s): Normo-ovulatory regularly cycling women with a previous poor response to ovarian hyperstimulation for IVF show follicular phase characteristics suggestive of ovarian aging.

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Citation

Beckers, Nicole G.M., Macklon, Nicholas S., Eijkemans, Marinus J.C. and Fauser, Bart C.J.M. (2002) Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging Fertility and Sterility, 78, (2), pp. 291-297. (doi:10.1016/S0015-0282(02)03227-2). (PMID:12137865).

More information

Published date: August 2002
Keywords: ovarian aging, ivf, poor response, follicular phase, follicles, fsh, progesterone, inhibin, ovary, menstrual cycle

Identifiers

Local EPrints ID: 185669
URI: http://eprints.soton.ac.uk/id/eprint/185669
ISSN: 0015-0282
PURE UUID: 6ac01408-dbe2-49df-b146-10ce2ffffa81

Catalogue record

Date deposited: 20 May 2011 08:01
Last modified: 18 Jul 2017 11:48

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Contributors

Author: Nicole G.M. Beckers
Author: Marinus J.C. Eijkemans
Author: Bart C.J.M. Fauser

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