Gonadotropin therapy for the treatment of anovulation and for ovarian hyperstimulation for IVF
Gonadotropin therapy for the treatment of anovulation and for ovarian hyperstimulation for IVF
Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose is too high, risking ovarian hyperstimulation syndrome. A major improvement to this approach would, therefore, be the ability to use initial screening characteristics to assess the individual FSH threshold beforehand. For IVF treatment, interfering in the process of single dominant follicle selection in ovulatory women by late follicular phase administration of low doses of FSH may result in a significantly reduced duration of stimulation and amounts of exogenous FSH preparations used. Less monitoring would be required and chances for short-term complications or long term risks may be reduced.
fsh window, anovulation, step-down, minimal hyperstimulation, ivf
159-161
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, Bart C.J.M.
0edf5e0f-12db-4ca9-bf9c-00e85b7f4a3e
25 January 2002
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, Bart C.J.M.
0edf5e0f-12db-4ca9-bf9c-00e85b7f4a3e
Macklon, Nicholas S. and Fauser, Bart C.J.M.
(2002)
Gonadotropin therapy for the treatment of anovulation and for ovarian hyperstimulation for IVF.
Molecular and Cellular Endocrinology, 186 (2), .
(doi:10.1016/S0303-7207(01)00660-8).
(PMID:11900890)
Abstract
Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose is too high, risking ovarian hyperstimulation syndrome. A major improvement to this approach would, therefore, be the ability to use initial screening characteristics to assess the individual FSH threshold beforehand. For IVF treatment, interfering in the process of single dominant follicle selection in ovulatory women by late follicular phase administration of low doses of FSH may result in a significantly reduced duration of stimulation and amounts of exogenous FSH preparations used. Less monitoring would be required and chances for short-term complications or long term risks may be reduced.
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Published date: 25 January 2002
Keywords:
fsh window, anovulation, step-down, minimal hyperstimulation, ivf
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Local EPrints ID: 185673
URI: http://eprints.soton.ac.uk/id/eprint/185673
PURE UUID: 6bb88725-197b-4740-80c2-ec453a7efdfd
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Date deposited: 19 May 2011 08:36
Last modified: 14 Mar 2024 03:15
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Author:
Nicholas S. Macklon
Author:
Bart C.J.M. Fauser
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