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Impact of ovarian hyperstimulation on the luteal phase

Impact of ovarian hyperstimulation on the luteal phase
Impact of ovarian hyperstimulation on the luteal phase
The contemporary approach to ovarian stimulation in IVF treatment results in supraphysiological concentrations of progesterone and oestrogen in the luteal phase. These sex steroids act directly and indirectly to mature the endometrium, thus influencing its receptivity to implantation. The development of endometrial receptivity is a complex process that may be altered by inappropriate exposure to sex steroids. Alterations in the oestrogen to progesterone ratio, growth factor concentrations and cell adhesion molecule profiles may occur after ovarian stimulation, potentially affecting the receptivity of the endometrium. Recent clinical IVF studies have shown that implantation rates and corpus luteum function are influenced by oestrogen concentrations during the early luteal phase. Few comparative studies have been performed, but after ovarian stimulation there is a reduced implantation rate and a higher pregnancy loss rate before pregnancies can be detected clinically compared with natural cycle conceptions. Novel approaches to ovarian stimulation aimed at achieving a more physiological luteal phase endocrinology are now being developed. Data from a recent pilot study by our laboratory, involving minimal ovarian hyperstimulation and no luteal phase support, are discussed.
0022-4251
101-108
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484

Macklon, N.S. and Fauser, B.C. (2000) Impact of ovarian hyperstimulation on the luteal phase. Reproduction, 55, 101-108. (PMID:10889839)

Record type: Article

Abstract

The contemporary approach to ovarian stimulation in IVF treatment results in supraphysiological concentrations of progesterone and oestrogen in the luteal phase. These sex steroids act directly and indirectly to mature the endometrium, thus influencing its receptivity to implantation. The development of endometrial receptivity is a complex process that may be altered by inappropriate exposure to sex steroids. Alterations in the oestrogen to progesterone ratio, growth factor concentrations and cell adhesion molecule profiles may occur after ovarian stimulation, potentially affecting the receptivity of the endometrium. Recent clinical IVF studies have shown that implantation rates and corpus luteum function are influenced by oestrogen concentrations during the early luteal phase. Few comparative studies have been performed, but after ovarian stimulation there is a reduced implantation rate and a higher pregnancy loss rate before pregnancies can be detected clinically compared with natural cycle conceptions. Novel approaches to ovarian stimulation aimed at achieving a more physiological luteal phase endocrinology are now being developed. Data from a recent pilot study by our laboratory, involving minimal ovarian hyperstimulation and no luteal phase support, are discussed.

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Published date: 2000

Identifiers

Local EPrints ID: 185681
URI: http://eprints.soton.ac.uk/id/eprint/185681
ISSN: 0022-4251
PURE UUID: f8059414-26cb-494e-bff3-8f3fc5b41090

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Date deposited: 20 May 2011 13:08
Last modified: 08 Jan 2022 08:42

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Contributors

Author: N.S. Macklon
Author: B.C. Fauser

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