The University of Southampton
University of Southampton Institutional Repository

Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms

Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms
Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms
Objective: To establish the influence of fetal behavior states
on venous and arterial pulmonary blood flow velocity waveforms
in the normally developing term fetus.
Methods: The relation between venous and arterial pulmonary
blood flow velocity waveforms and fetal behavior
states was investigated in 18 normal term fetuses. Recordings
of the venous pulmonary blood flow velocity waveforms
were obtained just proximal to the entrance in the left
atrium, and the arterial pulmonary blood flow velocity
waveforms were taken from the most proximal branch of the
pulmonary artery in the same lung using color Doppler
imaging. Time-averaged peak systolic, peak diastolic, and
end-diastolic flow velocity; peak systolic to peak diastolic
ratio; pulsatility index; and fetal heart rate were calculated
from both venous and arterial Doppler recordings obtained
during behavior states 1F (quiet sleep) and 2F (active sleep).
Fetal behavior states were determined from combined recordings
of fetal eye and body movements.
Results: Recordings of sufficient quality for analysis were
obtained from ten fetuses. Venous pulmonary blood flow
velocity waveforms demonstrated a statistically significant
increase in time-averaged peak diastolic and end-diastolic
velocity during fetal behavior state 2F. No behavior-staterelated
changes were observed for the arterial pulmonary
blood flow velocity waveform.
Conclusion: The data suggest an increased pressure gradient
between the pulmonary venous system and the left
atrium during behavior state 2F. Flow velocity waveforms
from the proximal arterial pulmonary branch are independent
of behavioral state.
0029-7844
184-188
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Laudy, Jacqueline A. M.
7434fd95-63bc-48e2-b520-5cb24aa51d19
Mulder, Paul G. H.
a62cb665-2160-4014-8cfe-e5698f442191
Wladimiroff, Juriy W.
15258b5b-a7c6-4bd3-8074-6738da746977
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Laudy, Jacqueline A. M.
7434fd95-63bc-48e2-b520-5cb24aa51d19
Mulder, Paul G. H.
a62cb665-2160-4014-8cfe-e5698f442191
Wladimiroff, Juriy W.
15258b5b-a7c6-4bd3-8074-6738da746977

Macklon, Nicholas S., Laudy, Jacqueline A. M., Mulder, Paul G. H. and Wladimiroff, Juriy W. (1999) Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms. Obstetrics and Gynecology, 93 (2), 184-188. (PMID:9932552)

Record type: Article

Abstract

Objective: To establish the influence of fetal behavior states
on venous and arterial pulmonary blood flow velocity waveforms
in the normally developing term fetus.
Methods: The relation between venous and arterial pulmonary
blood flow velocity waveforms and fetal behavior
states was investigated in 18 normal term fetuses. Recordings
of the venous pulmonary blood flow velocity waveforms
were obtained just proximal to the entrance in the left
atrium, and the arterial pulmonary blood flow velocity
waveforms were taken from the most proximal branch of the
pulmonary artery in the same lung using color Doppler
imaging. Time-averaged peak systolic, peak diastolic, and
end-diastolic flow velocity; peak systolic to peak diastolic
ratio; pulsatility index; and fetal heart rate were calculated
from both venous and arterial Doppler recordings obtained
during behavior states 1F (quiet sleep) and 2F (active sleep).
Fetal behavior states were determined from combined recordings
of fetal eye and body movements.
Results: Recordings of sufficient quality for analysis were
obtained from ten fetuses. Venous pulmonary blood flow
velocity waveforms demonstrated a statistically significant
increase in time-averaged peak diastolic and end-diastolic
velocity during fetal behavior state 2F. No behavior-staterelated
changes were observed for the arterial pulmonary
blood flow velocity waveform.
Conclusion: The data suggest an increased pressure gradient
between the pulmonary venous system and the left
atrium during behavior state 2F. Flow velocity waveforms
from the proximal arterial pulmonary branch are independent
of behavioral state.

This record has no associated files available for download.

More information

Published date: February 1999

Identifiers

Local EPrints ID: 185691
URI: http://eprints.soton.ac.uk/id/eprint/185691
ISSN: 0029-7844
PURE UUID: 5eec5332-b87f-432d-b91d-cf7af6f7b413

Catalogue record

Date deposited: 12 May 2011 09:26
Last modified: 08 Jan 2022 14:37

Export record

Contributors

Author: Nicholas S. Macklon
Author: Jacqueline A. M. Laudy
Author: Paul G. H. Mulder
Author: Juriy W. Wladimiroff

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×