The University of Southampton
University of Southampton Institutional Repository

Fetal cardiac function and septal thickness in diabetic pregnancy: a controlled observational and reproducibility study

Record type: Article

Objective: To determine the reproducibility of duplex Doppler waveform analysis and fetal cardiac interventricular septal thickness measurement and to compare these parameters in matched pregnancies with and without well-controlled maternal Type 1 diabetes at 18–20 weeks of gestation.

Design: A prospective blind twin cohort study and a blinded inter-observer and intra-observer agreement study.

Setting: A tertiary referral prenatal diagnostic unit within a university hospital.

Results: Good inter- and intra-observer agreement was found for the measurement of transvalvular peak flow velocities and the duration of ventricular ejection in the fetal heart. Inter-observer agreement for aortic flow acceleration rate was poor. M-mode measurement of interventricular septal thickness showed moderate reproducibility. The mean (SD) width of the interventricular septum in the fetuses of well controlled diabetic women was 2.1 mm (0.2 mm), and was significantly greater (P= 0.01) when compared with the corresponding value in matched controls [1.9 mm (0.2 mm)]. No cardiac functional differences were evident.

Conclusions: On-screen video analysis of Doppler cardiac flow waveforms and M-mode measurement of intraventricular septal thickness demonstrated good reproducibility. The fetuses of well controlled diabetic pregnancies demonstrated signs of altered cardiac morphology early in pregnancy, before any evident alterations in cardiac function.

Full text not available from this repository.

Citation

Macklon, N.S., Hop, W.C. and Wladimiroff, J.W. (1998) Fetal cardiac function and septal thickness in diabetic pregnancy: a controlled observational and reproducibility study British Journal of Obstetrics and Gynaecology, 105, (6), pp. 661-666. (doi:10.1111/j.1471-0528.1998.tb10182.x). (PMID:9647158).

More information

Published date: June 1998

Identifiers

Local EPrints ID: 185695
URI: http://eprints.soton.ac.uk/id/eprint/185695
ISSN: 0306-5456
PURE UUID: defea21f-170c-4b71-9e72-849021f7704f

Catalogue record

Date deposited: 19 May 2011 08:38
Last modified: 18 Jul 2017 11:48

Export record

Altmetrics


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×