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Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin

Macklon, N.S., Greer, I.A., Reid, A.W. and Walker, I.D. (1995) Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin Blood Coagulation & Fibrinolysis, 6, (7), pp. 672-675. (PMID:8562839).

Record type: Article

Abstract

Pregnancy limits the therapeutic options for managing thrombocytopenia which occurs in 5% of patients on heparin. We describe a case of extensive thromboembolism associated with antithrombin (AT) deficiency complicated by thrombocytopenia which resolved when low-molecular-weight heparin was instituted. A primigravid woman presented at 11 weeks gestation with bilateral femoral occlusive thrombi extending above the renal veins. Investigations revealed AT deficiency, thrombocytopenia and renal infarction. After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.

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Published date: October 1995

Identifiers

Local EPrints ID: 185707
URI: http://eprints.soton.ac.uk/id/eprint/185707
ISSN: 0957-5235
PURE UUID: d850cb36-8fa8-4554-90d6-33ebcf210400

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Date deposited: 20 May 2011 13:00
Last modified: 18 Jul 2017 11:48

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Contributors

Author: N.S. Macklon
Author: I.A. Greer
Author: A.W. Reid
Author: I.D. Walker

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