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Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria

Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria
Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria
This study examined motor control in 61 early and continuously treated patients with phenylketonuria (PKU) and 69 control participants, aged 7 to 14 years. The pursuit task demanded concurrent planning and execution of unpredictable movements, whereas the tracking task required a highly automated circular movement that could be planned in advance. PKU patients showed significantly poorer motor control in both tasks compared with control participants. Deficits were particularly observed for younger patients (age < 11 years). Differences between control participants and PKU patients were significantly greater in the pursuit task compared with the tracking task, indicating more serious deficits when a higher level of controlled processing is required. Correlations with historical phenylalanine levels indicated a later maturation of the level of control required by the pursuit task compared with the tracking task.
0894-4105
369-79
Huijbregts, S.C.J.
1268dc4d-9c81-4452-9da6-82cdc9dd39f8
de Sonneville, L.M.J.
38de127a-43ac-48f9-a0a5-95e5ad2baa5d
van Spronsen, F.J.
7f022d8f-cc4d-4ba5-813e-0b2bd2051b96
Berends, I.E.
787b6761-508d-4d53-80cc-1af2dd3afbbc
Licht, R.
f00f825e-915f-4306-a530-413c43765897
Verkerk, P.H.
9e6e1fa8-9ef8-4189-af98-b75b8f636c97
Sergeant, J.A.
2f434c2e-8247-4721-b4b0-b0d1849c843f
Huijbregts, S.C.J.
1268dc4d-9c81-4452-9da6-82cdc9dd39f8
de Sonneville, L.M.J.
38de127a-43ac-48f9-a0a5-95e5ad2baa5d
van Spronsen, F.J.
7f022d8f-cc4d-4ba5-813e-0b2bd2051b96
Berends, I.E.
787b6761-508d-4d53-80cc-1af2dd3afbbc
Licht, R.
f00f825e-915f-4306-a530-413c43765897
Verkerk, P.H.
9e6e1fa8-9ef8-4189-af98-b75b8f636c97
Sergeant, J.A.
2f434c2e-8247-4721-b4b0-b0d1849c843f

Huijbregts, S.C.J., de Sonneville, L.M.J., van Spronsen, F.J., Berends, I.E., Licht, R., Verkerk, P.H. and Sergeant, J.A. (2003) Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria. Neuropsychology, 17 (3), 369-79.

Record type: Article

Abstract

This study examined motor control in 61 early and continuously treated patients with phenylketonuria (PKU) and 69 control participants, aged 7 to 14 years. The pursuit task demanded concurrent planning and execution of unpredictable movements, whereas the tracking task required a highly automated circular movement that could be planned in advance. PKU patients showed significantly poorer motor control in both tasks compared with control participants. Deficits were particularly observed for younger patients (age < 11 years). Differences between control participants and PKU patients were significantly greater in the pursuit task compared with the tracking task, indicating more serious deficits when a higher level of controlled processing is required. Correlations with historical phenylalanine levels indicated a later maturation of the level of control required by the pursuit task compared with the tracking task.

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Published date: 2003

Identifiers

Local EPrints ID: 18574
URI: http://eprints.soton.ac.uk/id/eprint/18574
ISSN: 0894-4105
PURE UUID: 743039e9-b188-4d5c-8f92-156083f90fc5

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Date deposited: 02 Dec 2005
Last modified: 08 Jan 2022 00:59

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Contributors

Author: S.C.J. Huijbregts
Author: L.M.J. de Sonneville
Author: F.J. van Spronsen
Author: I.E. Berends
Author: R. Licht
Author: P.H. Verkerk
Author: J.A. Sergeant

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