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MRI-assessed volume of left and right hippocampi in females correlates with the relative length of the second and fourth fingers (the 2D:4D ratio)

MRI-assessed volume of left and right hippocampi in females correlates with the relative length of the second and fourth fingers (the 2D:4D ratio)
MRI-assessed volume of left and right hippocampi in females correlates with the relative length of the second and fourth fingers (the 2D:4D ratio)
Atrophy of the left or right side of the hippocampus has been related to cognitive deficits and psychiatric disease. In this study, we examined the correlation between the hippocampal volume laterality index and the relative lengths of the second (index finger) and fourth (ring finger) digits (2D:4D) in healthy female subjects. The 2D:4D ratio is fixed in utero, and the ratio is higher in women than in men. There is evidence that this ratio is an indicator of the intrauterine concentration of testosterone, which influences the development of different regions of the brain. Assessing the volume of different parts of the brain of 40 healthy adult female students by magnetic resonance imaging (MRI), we found that the 2D:4D ratio was associated with an asymmetry in the hippocampal sub-regions. Smaller volume on the left side was found in the posterior part of the hippocampus in females with a low (masculine type) 2D:4D ratio. On the other hand, smaller volume on the left side was found in the middle part of the hippocampus in females with a high (female type) 2D:4D ratio. Thus, the development of the middle and posterior regions of the hippocampal formation may respond in opposite ways to prenatal levels of testosterone. Other brain regions such as the amygdala, the cerebral cortex, the total volume hippocampus, and the head of the hippocampus did not show such a difference.
brain laterality, 2D:4D ratio, testosterone, hippocampus volume
0925-4927
199-210
Kallai, Janos
6f5d43a8-e4c5-448b-a820-d12e727276b9
Csathó, Árpád
27b2697f-c3be-49b5-83ec-51a19125808c
Kövér, Ferenc
0dbeb84c-60e9-4833-ae0f-5e2413f6e17f
Makány, Tamás
4030e720-c60e-4dd6-89ef-50d5ffdeb280
Nemes, János
c23bd9f0-0c4e-45d6-90f7-a80be82b6403
Horváth, Krisztina
27a2d65f-2c88-45bf-b95c-4bb1c5150e94
Kovács, Norbert
f59d5c06-2126-410e-8e0e-803024d2d629
Manning, John T.
9f768793-0e5f-4aec-9267-52e3e9d1e81c
Nadel, Lynn
33178522-17f7-43ad-8de0-e6f3af901b66
Nagy, Ferenc
6b360101-f2ce-4733-bd8f-bc28caec41fb
Kallai, Janos
6f5d43a8-e4c5-448b-a820-d12e727276b9
Csathó, Árpád
27b2697f-c3be-49b5-83ec-51a19125808c
Kövér, Ferenc
0dbeb84c-60e9-4833-ae0f-5e2413f6e17f
Makány, Tamás
4030e720-c60e-4dd6-89ef-50d5ffdeb280
Nemes, János
c23bd9f0-0c4e-45d6-90f7-a80be82b6403
Horváth, Krisztina
27a2d65f-2c88-45bf-b95c-4bb1c5150e94
Kovács, Norbert
f59d5c06-2126-410e-8e0e-803024d2d629
Manning, John T.
9f768793-0e5f-4aec-9267-52e3e9d1e81c
Nadel, Lynn
33178522-17f7-43ad-8de0-e6f3af901b66
Nagy, Ferenc
6b360101-f2ce-4733-bd8f-bc28caec41fb

Kallai, Janos, Csathó, Árpád, Kövér, Ferenc, Makány, Tamás, Nemes, János, Horváth, Krisztina, Kovács, Norbert, Manning, John T., Nadel, Lynn and Nagy, Ferenc (2005) MRI-assessed volume of left and right hippocampi in females correlates with the relative length of the second and fourth fingers (the 2D:4D ratio). Psychiatry Research: Neuroimaging, 140 (2), 199-210. (doi:10.1016/j.pscychresns.2004.05.010).

Record type: Article

Abstract

Atrophy of the left or right side of the hippocampus has been related to cognitive deficits and psychiatric disease. In this study, we examined the correlation between the hippocampal volume laterality index and the relative lengths of the second (index finger) and fourth (ring finger) digits (2D:4D) in healthy female subjects. The 2D:4D ratio is fixed in utero, and the ratio is higher in women than in men. There is evidence that this ratio is an indicator of the intrauterine concentration of testosterone, which influences the development of different regions of the brain. Assessing the volume of different parts of the brain of 40 healthy adult female students by magnetic resonance imaging (MRI), we found that the 2D:4D ratio was associated with an asymmetry in the hippocampal sub-regions. Smaller volume on the left side was found in the posterior part of the hippocampus in females with a low (masculine type) 2D:4D ratio. On the other hand, smaller volume on the left side was found in the middle part of the hippocampus in females with a high (female type) 2D:4D ratio. Thus, the development of the middle and posterior regions of the hippocampal formation may respond in opposite ways to prenatal levels of testosterone. Other brain regions such as the amygdala, the cerebral cortex, the total volume hippocampus, and the head of the hippocampus did not show such a difference.

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More information

Published date: 2005
Keywords: brain laterality, 2D:4D ratio, testosterone, hippocampus volume

Identifiers

Local EPrints ID: 18636
URI: http://eprints.soton.ac.uk/id/eprint/18636
ISSN: 0925-4927
PURE UUID: 45ae805d-1229-415d-8926-7d254ccd94c5

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Date deposited: 18 Jan 2006
Last modified: 15 Jul 2019 19:28

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