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Psychological stress and wound healing in humans: a systematic review and meta-analysis

Psychological stress and wound healing in humans: a systematic review and meta-analysis
Psychological stress and wound healing in humans: a systematic review and meta-analysis
Objective: the current review aims to synthesize existing knowledge about the relationship between psychological stress and wound healing.

Methods: systematic search strategy was conducted using electronic databases to search for published articles up to the end of October 2007. The reference lists of retrieved articles were inspected for further studies and citation searches were conducted. In addition, a meta-analysis of a subset of studies was conducted to provide a quantitative estimation of the influence of stress on wound healing.

Results: twenty-two papers met the inclusion criteria of the systematic review and a subsample of 11 was included in a meta-analysis. The studies assessed the impact of stress on the healing of a variety of wound types in different contexts, including acute and chronic clinical wounds, experimentally created punch biopsy and blister wounds, and minor damage to the skin caused by tape stripping. Seventeen studies in the systematic review reported that stress was associated with impaired healing or dysregulation of a biomarker related to wound healing. The relationship between stress and wound healing estimated by the meta-analysis was r=?0.42 (95% CI=?0.51 to ?0.32) (P<.01).

Conclusion: attention now needs to be directed towards investigating potential moderators of the relationship, mediating mechanisms underpinning the association, as well as the demonstration of a causal link by the development of experimental interventions in healthy populations
0022-3999
253-271
Walburn, Jessica
413a087b-30d4-4146-8742-7e72402fc883
Vedhara, Kavita
6d2f404c-d390-4019-b704-410a93b89910
Hankins, Matthew
ce4b7d68-3320-4af4-9dd7-3537a4b07219
Rixon, Lorna
a9040465-4f96-4ed0-bcf9-7c0b306d311b
Weinman, John
d84c2633-696c-4731-b372-92a8d552276c
Walburn, Jessica
413a087b-30d4-4146-8742-7e72402fc883
Vedhara, Kavita
6d2f404c-d390-4019-b704-410a93b89910
Hankins, Matthew
ce4b7d68-3320-4af4-9dd7-3537a4b07219
Rixon, Lorna
a9040465-4f96-4ed0-bcf9-7c0b306d311b
Weinman, John
d84c2633-696c-4731-b372-92a8d552276c

Walburn, Jessica, Vedhara, Kavita, Hankins, Matthew, Rixon, Lorna and Weinman, John (2009) Psychological stress and wound healing in humans: a systematic review and meta-analysis. Journal of Psychosomatic Research, 67 (3), 253-271. (doi:10.1016/j.jpsychores.2009.04.002).

Record type: Article

Abstract

Objective: the current review aims to synthesize existing knowledge about the relationship between psychological stress and wound healing.

Methods: systematic search strategy was conducted using electronic databases to search for published articles up to the end of October 2007. The reference lists of retrieved articles were inspected for further studies and citation searches were conducted. In addition, a meta-analysis of a subset of studies was conducted to provide a quantitative estimation of the influence of stress on wound healing.

Results: twenty-two papers met the inclusion criteria of the systematic review and a subsample of 11 was included in a meta-analysis. The studies assessed the impact of stress on the healing of a variety of wound types in different contexts, including acute and chronic clinical wounds, experimentally created punch biopsy and blister wounds, and minor damage to the skin caused by tape stripping. Seventeen studies in the systematic review reported that stress was associated with impaired healing or dysregulation of a biomarker related to wound healing. The relationship between stress and wound healing estimated by the meta-analysis was r=?0.42 (95% CI=?0.51 to ?0.32) (P<.01).

Conclusion: attention now needs to be directed towards investigating potential moderators of the relationship, mediating mechanisms underpinning the association, as well as the demonstration of a causal link by the development of experimental interventions in healthy populations

Full text not available from this repository.

More information

Published date: September 2009

Identifiers

Local EPrints ID: 187311
URI: http://eprints.soton.ac.uk/id/eprint/187311
ISSN: 0022-3999
PURE UUID: 204ece19-1431-46c6-9ac2-476348a4cd8d

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Date deposited: 17 May 2011 10:27
Last modified: 16 Jul 2019 23:36

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