The University of Southampton
University of Southampton Institutional Repository

Self-taken pharyngeal and rectal swabs are appropriate for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in asymptomatic men who have sex with men

Record type: Article

Introduction: Self-taken specimens from men who have sex with men (MSM) could be important in reducing high levels of demand on sexual health services. The performance of self-taken specimens for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) from both pharyngeal and rectal sites in asymptomatic MSM was assessed.

Methods: MSM were examined according to clinic protocol: a rectal and pharyngeal swab for GC culture and a rectal swab for the CT strand displacement assay. An extra set of nurse-taken and self-taken pharyngeal and rectal specimens were also requested and were tested using the Aptima Combo 2 assay and the result compared with the routine clinic result, which was considered the gold standard.

Results: A total of 272 MSM was recruited and the sensitivity and specificity of nurse-taken and patient-taken swabs, respectively, was as follows: rectal GC: 94.9% and 90.1% (nurse); 92.3% and 87.9% (patient); pharyngeal GC: 88.2% and 91.8% (nurse); 100% and 87.8% (patient); rectal CT: 80.0% and 99.6% (nurse); 91.4% and 98.2% (patient). No significant difference in sensitivity or specificity was observed between the nurse-taken and the patient-taken rectal swabs for either GC or CT. For the detection of GC from the pharynx, comparable sensitivities were achieved between nurse-taken and patient-taken swabs (p?=?0.5); however, a significant difference in specificity was observed (p?=?0.006). This was due to a higher number of false GC-positive self-taken pharyngeal swabs from patients with high rates (90.9%; 10/11) of confirmed concurrent GC infection in different anatomical sites.

Conclusions: MSM are able to collect self-taken rectal and pharyngeal swabs that are comparable to those taken by clinicians.

Full text not available from this repository.

Citation

Alexander, S., Ison, C., Parry, J., Llewellyn, C., Wayal, S., Richardson, D., Phillips, A., Smith, H. and Fisher, M. Brighton Home Sampling Kits Steering Group. (2008) Self-taken pharyngeal and rectal swabs are appropriate for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in asymptomatic men who have sex with men Sexually Transmitted Infections, 84, (6), pp. 488-492. (doi:10.1136/sti.2008.031443). (PMID:19028953).

More information

Published date: November 2008

Identifiers

Local EPrints ID: 187353
URI: http://eprints.soton.ac.uk/id/eprint/187353
ISSN: 1368-4973
PURE UUID: 7620c4fa-3f92-4b13-8297-baaf4a6628b3

Catalogue record

Date deposited: 17 May 2011 13:53
Last modified: 18 Jul 2017 11:45

Export record

Altmetrics

Contributors

Author: S. Alexander
Author: C. Ison
Author: J. Parry
Author: C. Llewellyn
Author: S. Wayal
Author: D. Richardson
Author: A. Phillips
Author: H. Smith
Author: M. Fisher

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×