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Peritoneal healing and adhesion formation/reformation

Peritoneal healing and adhesion formation/reformation
Peritoneal healing and adhesion formation/reformation
Intra-abdominal adhesion formation and reformation after surgery is a cause of significant morbidity, resulting in infertility and pain. The understanding of the pathogenesis of adhesion formation and reformation especially at the cellular and molecular level can help to further develop more effective treatments for the prevention of adhesion formation and reformation. Following an injury to the peritoneum, fibrinolytic activity over the peritoneal surface decreases, leading to changes in the expression and synthesis of various cellular mediators and in the remodelling of the connective tissue. The cellular response to peritoneal injury and adhesion formation and reformation are reviewed. Analysis of the available literature data on the cellular mediators in the peritoneal fluid showed variation in results from different investigators. The potential sources of variability and error are examined. It is still unclear if there is significant individual variation in the peritoneal response to injury.
adhesion formation, cytokines, fibrinolysis, metalloproteinases, peritoneal fluid
1355-4786
556-566
Cheong, Y.C.
4efbba2a-3036-4dce-82f1-8b4017952c83
Laird, S.M.
9cb82d74-d4a7-4372-8d87-7f902af195c1
Li, T.C.
e5ba5bf8-481f-4879-9741-45e75333fea0
Shelton, J.B.
a6c50fc2-532a-42ef-a278-b95e1275e400
Ledger, W.L.
bc2a8d8e-c355-4f93-acb4-ea675ea519a5
Cooke, I.D.
2748ef8a-7fcd-40b1-9db9-ca5bcee44464
Cheong, Y.C.
4efbba2a-3036-4dce-82f1-8b4017952c83
Laird, S.M.
9cb82d74-d4a7-4372-8d87-7f902af195c1
Li, T.C.
e5ba5bf8-481f-4879-9741-45e75333fea0
Shelton, J.B.
a6c50fc2-532a-42ef-a278-b95e1275e400
Ledger, W.L.
bc2a8d8e-c355-4f93-acb4-ea675ea519a5
Cooke, I.D.
2748ef8a-7fcd-40b1-9db9-ca5bcee44464

Cheong, Y.C., Laird, S.M., Li, T.C., Shelton, J.B., Ledger, W.L. and Cooke, I.D. (2001) Peritoneal healing and adhesion formation/reformation. Human Reproduction Update, 7 (6), 556-566. (doi:10.1093/humupd/7.6.556). (PMID:11727862)

Record type: Article

Abstract

Intra-abdominal adhesion formation and reformation after surgery is a cause of significant morbidity, resulting in infertility and pain. The understanding of the pathogenesis of adhesion formation and reformation especially at the cellular and molecular level can help to further develop more effective treatments for the prevention of adhesion formation and reformation. Following an injury to the peritoneum, fibrinolytic activity over the peritoneal surface decreases, leading to changes in the expression and synthesis of various cellular mediators and in the remodelling of the connective tissue. The cellular response to peritoneal injury and adhesion formation and reformation are reviewed. Analysis of the available literature data on the cellular mediators in the peritoneal fluid showed variation in results from different investigators. The potential sources of variability and error are examined. It is still unclear if there is significant individual variation in the peritoneal response to injury.

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More information

Published date: November 2001
Keywords: adhesion formation, cytokines, fibrinolysis, metalloproteinases, peritoneal fluid

Identifiers

Local EPrints ID: 187871
URI: http://eprints.soton.ac.uk/id/eprint/187871
ISSN: 1355-4786
PURE UUID: c3da33de-dc9c-4af4-b265-973291a50ebe
ORCID for Y.C. Cheong: ORCID iD orcid.org/0000-0001-7687-4597

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Date deposited: 20 May 2011 13:05
Last modified: 15 Mar 2024 03:30

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Contributors

Author: Y.C. Cheong ORCID iD
Author: S.M. Laird
Author: T.C. Li
Author: J.B. Shelton
Author: W.L. Ledger
Author: I.D. Cooke

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