The University of Southampton
University of Southampton Institutional Repository

Methodologic issues in clinical trials for prevention or risk reduction in Osteoarthritis

Jordan, J.M., Sowers, M.F., Messier, S.P., Bradley, J., Arangio, G., Katz, J.N., Losina, E., Rovati, L., Batchell, N., Cooper, C., Spector, T., Zhang, W., Gardiner, J. and Wahba, M. (2011) Methodologic issues in clinical trials for prevention or risk reduction in Osteoarthritis Osteoarthritis and Cartilage, 19, (5), pp. 500-508. (doi:10.1016/j.joca.2010.10.031). (PMID:21396470).

Record type: Article


The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease. Disease definitions and their precise and sensitive measurement, identification of high-risk populations, the nature of the intervention (pharmaceutical, nutraceutical, behavioral) and its potential pleiotropic impacts on other organ systems are critical to consider. Because prevention trials may be prolonged, close attention to concomitant life changes and co-morbidities, adherence and participant retention in the trial is of primary importance, as is recognition of the potential for “preventive misconception” and “behavioral disinhibition” to affect the ability of the trial to show an effect of the intervention under study. None of these potential pitfalls precludes a successful and scientifically rigorous process and outcome. As technology improves the means to measure and predict the OA process and its clinical consequences, it will be increasingly possible to screen individuals for high-risk phenotypes, combining clinical factors with information from imaging, genetic, metabolic and other biomarkers and to impact this high-risk condition to avoid or delay OA both structurally and symptomatically.

Full text not available from this repository.

More information

Published date: May 2011
Keywords: prevention, clinical trial, obesity, injury, osteoarthritis


Local EPrints ID: 187991
ISSN: 1063-4584
PURE UUID: 17831a92-168c-43da-90c6-c03fb492cb1f
ORCID for C. Cooper: ORCID iD

Catalogue record

Date deposited: 19 May 2011 12:43
Last modified: 18 Jul 2017 11:43

Export record



Author: J.M. Jordan
Author: M.F. Sowers
Author: S.P. Messier
Author: J. Bradley
Author: G. Arangio
Author: J.N. Katz
Author: E. Losina
Author: L. Rovati
Author: N. Batchell
Author: C. Cooper ORCID iD
Author: T. Spector
Author: W. Zhang
Author: J. Gardiner
Author: M. Wahba

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.