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Total spontaneous resolution of a cyanoguanidine showing only conformational chirality

Total spontaneous resolution of a cyanoguanidine showing only conformational chirality
Total spontaneous resolution of a cyanoguanidine showing only conformational chirality
The total spontaneous resolution of N-(4-chlorophenyl)-N'-cyano-N,N",N"-trimethylguanidine, a compound which shows only conformational chirality, is described; variable temperature NMR experiments show that rotation of the dimethylamino group is rapid in solution at room temperature as is conformer interconversion by rotation of the arylmethylamino group.
absolute asymmetric-synthesis, solid-state, crystal environment, amide
1359-7345
61-62
Cunningham, I. D.
7e636eb2-301a-4485-9fc1-3ea7c4a2cac1
Coles, S. J.
503a9d9c-0380-4fcd-ad31-cd329255c08e
Hursthouse, M. B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Cunningham, I. D.
7e636eb2-301a-4485-9fc1-3ea7c4a2cac1
Coles, S. J.
503a9d9c-0380-4fcd-ad31-cd329255c08e
Hursthouse, M. B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da

Cunningham, I. D., Coles, S. J. and Hursthouse, M. B. (2000) Total spontaneous resolution of a cyanoguanidine showing only conformational chirality. Chemical Communications, (1), 61-62. (doi:10.1039/a907518f).

Record type: Article

Abstract

The total spontaneous resolution of N-(4-chlorophenyl)-N'-cyano-N,N",N"-trimethylguanidine, a compound which shows only conformational chirality, is described; variable temperature NMR experiments show that rotation of the dimethylamino group is rapid in solution at room temperature as is conformer interconversion by rotation of the arylmethylamino group.

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More information

Published date: 2000
Keywords: absolute asymmetric-synthesis, solid-state, crystal environment, amide

Identifiers

Local EPrints ID: 18851
URI: http://eprints.soton.ac.uk/id/eprint/18851
ISSN: 1359-7345
PURE UUID: 1a62254e-5768-40fb-b7a1-e8b626203322

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Date deposited: 20 Dec 2005
Last modified: 15 Mar 2024 06:08

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Contributors

Author: I. D. Cunningham
Author: S. J. Coles

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