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Thermally cleavable safety-catch linkers for solid phase chemistry

Russell, H. E., Luke, R. W. A. and Bradley, M. (2000) Thermally cleavable safety-catch linkers for solid phase chemistry Tetrahedron Letters, 41, (27), pp. 5287-5290. (doi:10.1016/S0040-4039(00)00807-8).

Record type: Article


Safety-catch linkers based on the sulfoxide/selenoxide syn elimination have been developed. Clean and efficient oxidation of the sulfide to the sulfoxide was achieved with the homogeneous oxidising system comprising of hexafluoroisopropanol (HFIP) and hydrogen peroxide. Elimination of the sulfoxide was only possible with the most activated of substrates, while the selenoxide underwent cleavage under much milder conditions.

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Published date: 1 July 2000
Keywords: organic-synthesis, acids


Local EPrints ID: 18854
ISSN: 0040-4039
PURE UUID: 6c697d5a-472a-4909-b513-d429b17ba548

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Date deposited: 15 Dec 2005
Last modified: 17 Jul 2017 16:34

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Author: H. E. Russell
Author: R. W. A. Luke
Author: M. Bradley

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