Letter to the editor. The t(4;9)(q11;q33) fuses CEP110 to KIT in a case of acute myeloid leukemia
Letter to the editor. The t(4;9)(q11;q33) fuses CEP110 to KIT in a case of acute myeloid leukemia
KIT is a class III receptor tyrosine kinase (RTK) that has an important role in hemopoiesis, particularly with regard to stem cell maintenance and mast cell development. KIT is normally activated by engagement with its ligand, stem cell factor, but a variety of acquired KIT point mutations have been described in acute myeloid leukemia (AML) and systemic mastocytosis that result in constitutive, ligand-independent activation. In contrast to other related RTKs such as PDGFRA, PDGFRB and FLT3, constitutive activation of KIT by gene fusion has not been described.
1049-1050
Grand, F.H.
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Waghorn, K.
60a6a26d-556b-41fc-84ee-dab95d63ab68
Ernst, T.
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Ohyashiki, K.
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Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
June 2011
Grand, F.H.
f4b9e5f4-28c4-44d2-9916-d852c2fdaef8
Waghorn, K.
60a6a26d-556b-41fc-84ee-dab95d63ab68
Ernst, T.
7b376e62-a796-419d-9c55-deda2770675f
Ohyashiki, K.
0830f286-2863-4dd6-9540-b030f646d1b1
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Grand, F.H., Waghorn, K., Ernst, T., Ohyashiki, K. and Cross, N.C.P.
(2011)
Letter to the editor. The t(4;9)(q11;q33) fuses CEP110 to KIT in a case of acute myeloid leukemia.
Leukemia, 25 (6), .
(doi:10.1038/leu.2011.40).
(PMID:21403647)
Abstract
KIT is a class III receptor tyrosine kinase (RTK) that has an important role in hemopoiesis, particularly with regard to stem cell maintenance and mast cell development. KIT is normally activated by engagement with its ligand, stem cell factor, but a variety of acquired KIT point mutations have been described in acute myeloid leukemia (AML) and systemic mastocytosis that result in constitutive, ligand-independent activation. In contrast to other related RTKs such as PDGFRA, PDGFRB and FLT3, constitutive activation of KIT by gene fusion has not been described.
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Accepted/In Press date: 15 March 2011
Published date: June 2011
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Local EPrints ID: 188565
URI: http://eprints.soton.ac.uk/id/eprint/188565
ISSN: 0887-6924
PURE UUID: 54b85f6e-cdd3-4117-9921-0c5fb243cef9
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Date deposited: 26 May 2011 08:12
Last modified: 15 Mar 2024 03:11
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Author:
F.H. Grand
Author:
K. Waghorn
Author:
T. Ernst
Author:
K. Ohyashiki
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