Andrew, R. J. and Mellor, J. M.
Synthesis of ?,?-unsaturated trifluoromethyl ketones from 4-dimethylamino-1,1,1-trifluorobut-3-ene-2-one by addition of Grignard reagents
Tetrahedron, 56, (37), . (doi:10.1016/S0040-4020(00)00597-4).
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Enaminones are available by reaction of 4-ethoxy-1,1,1-trifluorobut-3-ene-2-one with amines such as dimethylamine and they react with Grignard reagents to give ?, ?-unsaturated trifluoromethyl ketones in good yield by 1,4-addition followed by elimination. The generality of this procedure is contrasted with reactions based either on the use of organolithium nucleophiles, or the use of 4-alkoxy-?, ?-unsaturated trifluoromethyl ketones as electrophilic partners.
|Digital Object Identifier (DOI):
||addition, grignard reagents, organolithium, trifluoromethyl-ketones
alpha, beta-unsaturated ketones, stereoselective synthesis, efficientsynthesis, enamino ketones, (trifluoromethyl)trimethylsilane, condensation, inhibitors, methyl, esters
|8 September 2000||Published|
||16 Dec 2005
||16 Apr 2017 23:08
|Further Information:||Google Scholar|
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