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Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation

Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation
Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation
A novel thymidine analogue containing both 5-aminopropargyl and 2'-aminoethoxy modifications has been synthesised and incorporated into a triplex-forming oligonucleotide; the combination of the two amino groups on the same nucleoside greatly enhances triplex stability.
helix formation, mutagenesis
1359-7345
2315-2316
Sollogoub, M.
0f6829b1-2f62-40c8-bfa1-cab69c36b694
Dominguez, B.
435ed6bd-fbe0-44be-8818-7c8de5baa4bd
Fox, K.R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Sollogoub, M.
0f6829b1-2f62-40c8-bfa1-cab69c36b694
Dominguez, B.
435ed6bd-fbe0-44be-8818-7c8de5baa4bd
Fox, K.R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89

Sollogoub, M., Dominguez, B., Fox, K.R. and Brown, T. (2000) Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation. Chemical Communications, 23, 2315-2316. (doi:10.1039/b006268p).

Record type: Article

Abstract

A novel thymidine analogue containing both 5-aminopropargyl and 2'-aminoethoxy modifications has been synthesised and incorporated into a triplex-forming oligonucleotide; the combination of the two amino groups on the same nucleoside greatly enhances triplex stability.

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More information

Published date: 9 November 2000
Keywords: helix formation, mutagenesis
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 18873
URI: http://eprints.soton.ac.uk/id/eprint/18873
ISSN: 1359-7345
PURE UUID: a5c5eb03-9372-4b86-b01a-43ff02351a9f
ORCID for K.R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 21 Dec 2005
Last modified: 17 Dec 2019 02:04

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