Mitochondrial dysfunction leads to telomere attrition and genomic instability
Mitochondrial dysfunction leads to telomere attrition and genomic instability
Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging-associated pathologies. Telomere shortening and genomic instability have also been associated with replicative senescence, aging and cancer. Here we show that mitochondrial dysfunction leads to telomere attrition, telomere loss, and chromosome fusion and breakage, accompanied by apoptosis. An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria, suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability. Further, nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria. This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies.
apoptosis, mitochondria, mouse, oxidative stress, telomere
40-46
Liu, Lin
51bc0635-5ce3-4ade-9edf-624ec8a1750b
Trimarchi, James R.
dc15c269-2b07-41fb-b3e5-a9ac457c7994
Smith, Peter J. S.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Keefe, David L.
a1d0a08b-d76a-4d64-b2dd-4d1a5fc04451
October 2002
Liu, Lin
51bc0635-5ce3-4ade-9edf-624ec8a1750b
Trimarchi, James R.
dc15c269-2b07-41fb-b3e5-a9ac457c7994
Smith, Peter J. S.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Keefe, David L.
a1d0a08b-d76a-4d64-b2dd-4d1a5fc04451
Liu, Lin, Trimarchi, James R., Smith, Peter J. S. and Keefe, David L.
(2002)
Mitochondrial dysfunction leads to telomere attrition and genomic instability.
Aging Cell, 1 (1), .
(doi:10.1046/j.1474-9728.2002.00004.x).
Abstract
Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging-associated pathologies. Telomere shortening and genomic instability have also been associated with replicative senescence, aging and cancer. Here we show that mitochondrial dysfunction leads to telomere attrition, telomere loss, and chromosome fusion and breakage, accompanied by apoptosis. An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria, suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability. Further, nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria. This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies.
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Published date: October 2002
Keywords:
apoptosis, mitochondria, mouse, oxidative stress, telomere
Identifiers
Local EPrints ID: 188837
URI: http://eprints.soton.ac.uk/id/eprint/188837
ISSN: 1474-9718
PURE UUID: 2fc14a5e-664b-4fe9-b8de-664af91da6c3
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Date deposited: 17 Jun 2011 12:28
Last modified: 15 Mar 2024 03:38
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Author:
Lin Liu
Author:
James R. Trimarchi
Author:
David L. Keefe
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