Structure-activity relationships in anti-neoplastic: type I amphiphiles


Dymond, M.K. and Attard, G.S. (2000) Structure-activity relationships in anti-neoplastic: type I amphiphiles Biochemistry, 39, (6), p. 1572. (doi:10.1021/bi9950995).

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Description/Abstract

HDPC and ET-18-OMe, both type I amphiphiles and analogues of the naturally occurring biomembrane component lysophosphatidylcholine, are potent anti-neoplastic agents. A series of novel, type I amphiphiles have been synthesized, and their cytostatic activity against cancer cells in culture was determined. The data suggest that cytostatic activity is a generic property of type I amphiphiles. Furthermore, the primary target for these amphiphiles appears to be the inhibition of phosphatidylcholine synthesis via perturbation in the elastic properties of intracellular bilayer membranes.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/bi9950995
Subjects:
ePrint ID: 18898
Date :
Date Event
15 February 2000Published
Date Deposited: 17 Jan 2006
Last Modified: 16 Apr 2017 23:08
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/18898

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