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Structure-activity relationships in anti-neoplastic: type I amphiphiles

Dymond, M.K. and Attard, G.S. (2000) Structure-activity relationships in anti-neoplastic: type I amphiphiles Biochemistry, 39, (6), p. 1572. (doi:10.1021/bi9950995).

Record type: Article


HDPC and ET-18-OMe, both type I amphiphiles and analogues of the naturally occurring biomembrane component lysophosphatidylcholine, are potent anti-neoplastic agents. A series of novel, type I amphiphiles have been synthesized, and their cytostatic activity against cancer cells in culture was determined. The data suggest that cytostatic activity is a generic property of type I amphiphiles. Furthermore, the primary target for these amphiphiles appears to be the inhibition of phosphatidylcholine synthesis via perturbation in the elastic properties of intracellular bilayer membranes.

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Published date: 15 February 2000
Organisations: Chemistry


Local EPrints ID: 18898
PURE UUID: 024dce7a-03e5-42cf-9425-207e6813d565

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Date deposited: 17 Jan 2006
Last modified: 17 Jul 2017 16:34

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Author: M.K. Dymond
Author: G.S. Attard

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